Table 2

Motifs within Plasmodium spp. MRP nucleotide binding domains

Nucleotide Binding Domain

Motif

Consensus Sequence

Consensus in Plasmodium spp.

Location in pbMRP

NBD1

Walker A

GxxxxGK [S, T]

G [D, N] [I, V]GSG [E, K]T

714–722

Q loop

XQx

PQ [I, F]

753–755

ABC motif

LSGGQ

LSKGQ

808–812

Walker B

XILxDE

LYL [L, F]DD

954–959

D loop

LD

LD

964–965

H loop

XHx

Not identified

NBD2

Walker A

GxxxxGK [S, T]

G [K, R]SGAGKS

1705–1712

Q loop

XQx

PQS

1752–1754

ABC motif

LSGGQ

L [S, A]LVR

1835–1839

Walker B

XILxDE

L [L, V, I]LIDE

1849–1854

D loop

LD

Not identified

H loop

XHx

[S, A]HD

1895–1897

González-Pons et al. Malaria Journal 2009 8:1   doi:10.1186/1475-2875-8-1