Figure 3.

Three levels of antimalarial susceptibility for a slowly eliminated antimalarial with a multiphasic elimination profile (e.g chloroquine, piperaquine) are shown reflected by the respective minimum inhibitory concentrations (MIC); sensitive (S), resistant (R) and highly resistant (HR). Post treatment prophylaxis for sensitive parasites is six weeks. In this example increasing levels of resistance progressively shorten the PTP from six to three weeks (a) and then from three to two weeks (b).