Table 1

Frequency of haplotypes in different subsets of the host population









adults vs. children
 adults vs. new infections









Haplotype1
 Adults cross section2(n = 61)
 Children cross section2(n = 63)
 TRS3baseline samples (n = 109)
 TRS3new infections (n = 144)
 OR
 p4
 95% CI
 OR
 p4
 95% CI


n
 %
 n
 %
 n
 %
 n
 %





crt76 crt326 crt356
 0
 0
 0
 0
 0
 0
 1
 0.69
 -
 -
 -
 -
 -
 -
crt76 crt326 crt356 crt220
 1
 1.64
 1
 1.59
 0
 0
 0
 0
 0.97
 0.98
 0.06 – 15.83
 -
 -
 -
crt76 crt326 crt356 dhfr108 dhfr59
 0
 0
 0
 0
 3
 2.75
 0
 0
 -
 -
 -
 -
 -
 -
crt76 crt326 crt356 crt220 dhps540
 0
 0
 1
 1.59

0
 0
 -
 -
 -
 -
 -
 -
crt76 crt326 crt356 crt220 mdr86
 4
 6.56
 2
 3.17
 0
 0
 1
 0.69
 0.47
 0.39
 0.08 – 2.65
 0.1
 0.04
 0.01 – 0.91
crt76 crt326 crt356 crt220 dhfr108 dhfr59
 3
 4.92
 0
 0
 4
 3.67
 1
 0.69
 -
 -
 -
 0.14
 0.09
 0.01 – 1.33
crt76 crt326 crt356 dhfr108 dhfr59 mdr86
 8
 13.11
 4
 6.35
 15
 13.76
 8
 5.56
 0.45
 0.21
 0.13 – 1.58
 0.39
 0.07
 0.14 – 1.09
crt76 crt326 crt356 crt220 dhfr108 mdr86
 1
 1.64
 2
 3.17
 2
 1.83
 2
 1.39
 1.97
 0.59
 0.17 – 22.27
 0.85
 0.89
 0.75 – 9.5
crt76 crt326 crt356 dhfr108 dhfr59 mdr86 dhps540
 0
 0
 0
 0
 0
 0
 1
 0.69
 -
 -
 -
 -
 -
 -
crt76 crt326 crt356 crt220 dhfr108 dhfr59 mdr86
 40
 65.57
 53
 84.13
 85
 77.98
 126
 87.5
 2.78
 0.02
 1.18 – 6.56
 3.68
 0.001
 1.78 – 7.57
crt76 crt326 crt356 crt220 dhfr108 dhfr59 mdr86 dhps540
 2
 3.28
 0
 0
 0
 0
 4
 2.78
 -
 -
 -
 0.84
 0.85
 0.15 – 4.73
crt76 crt326 crt356 crt220 dhfr108 dhfr59 mdr1042 mdr184
 1
 1.64
 0
 0
 0
 0
 0
 0
 -
 -
 -
 -
 -
 -
crt76 crt326 crt356 crt220 dhfr108 dhfr59 mdr86 dhps437
 1
 1.64
 0
 0
 0
 0
 0
 0
 -
 -
 -
 -
 -
 -

1) Haplotypes represent 11 single nucleotide polymorphisms (SNPs) in 4 different genes. The remaining 14 SNPs tested but not listed equal to wildtype.

2) Cross-sectional samples include only individuals that have not been treated with antimalarial drugs in the 2 months prior to the survey.

3) TRS, treatment to reinfection study

4) Bold indicates p < 0.05

Schoepflin et al. Malaria Journal 2008 7:78   doi:10.1186/1475-2875-7-78

Open Data