Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine
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* Corresponding author: Céline Barnadas cbarnadas@free.fr
Malaria Journal 2008, 7:35 doi:10.1186/1475-2875-7-35
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Methodology
Céline Barnadas, David Kent, Lincoln Timinao, Jonah Iga, Laurie R Gray, Peter Siba, Ivo Mueller, Peter J Thomas, Peter A Zimmerman Malaria Journal 2011, 10:282 (24 September 2011) Monitoring P. vivax resistance to anti-malarial drugs in vivo and in vitro remaind challenging, but some molecular markers of resistance can be used in surveillance studies. A new high-throughput assay relevant markers of drug resistance was developed and assessed on Papua New Guinea patient isolates.
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Research
Fang Huang, Shuisen Zhou, Shaosen Zhang, Weidong Li, Hongwei Zhang Parasites & Vectors 2011, 4:80 (17 May 2011) This article is part of a collection on Aspects of parasitology in... There were four parasite populations in pvdhfr allele frequencies with wild-type and single and double mutants at three codons (58, 61 and 117) in Central China, which suggested that P.vivax may be relatively susceptible to pyrimethamine. Image: Map of distribution sentinel sites and mutant pvdhfr in Central China.
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Research
Molecular surveillance of Plasmodium vivax dhfr and dhps mutations in isolates from Afghanistan Sedigheh Zakeri, Mandana Afsharpad, Faezeh Ghasemi, Ahmad Raeisi, Najibullah Safi, Waqar Butt, Hoda Atta, Navid D Djadid Malaria Journal 2010, 9:75 (14 March 2010) A study monitoring Plasmodium vivax dhfr and dhps mutations in Afganistan, which is important for baseline information of polymorphisms of these two genes in this country. The PCR-RFLP applied to sample genetic analysis is a rapid method comparing to gene sequencing.
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Research
Sedigheh Zakeri, Shadi Motmaen, Mandana Afsharpad, Navid Djadid Malaria Journal 2009, 8:20 (28 January 2009) The paper provides information on P. vivax alleles of dhfr and dhps in Iran and other areas from where no basic information was previously available.
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Research
Natacha Mariette, Céline Barnadas, Christiane Bouchier, Magali Tichit, Didier Ménard Malaria Journal 2008, 7:219 (28 October 2008) In view of the high polymorphism of pfhrp2 and pfhrp3 genes, it was predicted that 9% of Malagasy isolates would not be detected by the existing PfHRP2-based RDTs currently recommended for Madagascar.
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