Table 1

Efficacy at day-28 of sulphadoxine/pyrimethamine (SP) versus amodiaquine (AQ)

SP

AQ

%

n

95% CI

%

n

95% CI

P value

ACPR

73.9

51

61.7–83.4

54.9

39

42.7–66.6

0.03

ETF

2.9

2

0.5–11.0

0

0

0.0–6.4

0.46

LCF

1.4

1

0.2–7.8

5.6

4

1.8–14.5

0.38

LPF

21.7

15

13.1–33.6

39.4

28

28.3–51.8

0.04

Failure rate

Before PCR-correction

26.1

18/69

15.7–36.5

45.1

32/71

33.4–57.3

0.02

After PCR-correction

11.6

8/69

5.5–22.1

28.2

20/71

17.7–38.7

0.019

ACPR = adequate clinical and parasitological response; ETF = early treatment failure; LTF = late treatment failure; LCF = late clinical failure; LPF = late parasitological failure

Nsimba et al. Malaria Journal 2008 7:31   doi:10.1186/1475-2875-7-31