NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity

doi:10.1186/1475-2875-7-251

Malaria Journal

Volume 7

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Greve B
Hoffmann P
Vonthein R
Kun J
Lell B
Mycko MP
Selmaj KW
Berger K
Weissert R
Kremsner PG

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Greve B
Hoffmann P
Vonthein R
Kun J
Lell B
Mycko MP
Selmaj KW
Berger K
Weissert R
Kremsner PG
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Research

NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity

Bernhard Greve¹^* , Peter Hoffmann¹^* , Reinhard Vonthein² , Jürgen Kun³ , Bertrand Lell³^,4 , Marcin P Mycko⁵ , Krysztof W Selmaj⁵ , Klaus Berger⁶ , Robert Weissert¹^,7 and Peter G Kremsner³^,4

¹Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Tübingen, Germany

²Department of Medical Biometry, University of Tübingen, Tübingen, Germany

³Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

⁴Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon

⁵Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland

⁶Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany

⁷Geneva Research Center, Merck Serono International SA, Geneva, Switzerland

author email corresponding author email* Contributed equally

Malaria Journal 2008, 7:251doi:10.1186/1475-2875-7-251


Published:	11 December 2008

Abstract

Background

Neutrophil cytosolic factor 1, p47^phox(NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI.

Methods

NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS).

Results

Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients.

Conclusion

The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.