NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
- Equal contributors
1 Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Tübingen, Germany
2 Department of Medical Biometry, University of Tübingen, Tübingen, Germany
3 Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
4 Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
5 Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland
6 Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
7 Geneva Research Center, Merck Serono International SA, Geneva, Switzerland
Malaria Journal 2008, 7:251 doi:10.1186/1475-2875-7-251Published: 11 December 2008
Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI.
NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS).
Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients.
The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.