Table 2 |
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Intention to treat analysis: Clinical and biological responses to IV glucose or sublingual sugar administration among children with hypoglycaemia (BGC < 60 mg/dl) in Mali |
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| Sublingual Sugar (SLS) |
Intravenous Glucose (IVG) |
p |
|
| n = 14 (95%CI) |
n = 9 (95%CI) |
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|
|
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| Primary Outcome measure |
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| - Treatment Response (reaching 60 mg within 40 minutes) |
10/14 (71%) |
6/9 (67%) |
0.81 |
| Secondary outcome measures |
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| - Early treatment responsea |
9/14 (64.3%) |
6/9 (67%) |
0.91 |
| - Relapseb (as % of treatment responders) |
3/10 (30%) |
1/6 (17%) |
0.55 |
| -CGmaxd(mg/dl) |
43.4 (25.8–62.5) |
46.2 (19.1–73.2) |
0.60 |
| -Treatment delay (mins)e |
< 5 |
18.9 (6.4–31.6) |
- |
| Case Fatality |
1 (7%) |
1 (11%) |
NS |
|
|
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a defined as a significant blood glucose gain (> 10 mg/dl) at or before 20 minutes b defined as children who reached a normal glycaemia 3.3 mmol/L (60 mg/dl), but failed to maintain it c defined as the difference between baseline BGC and the peak glucose concentration (on the first-line treatment) within the first 40 minutes d the time from confirmation of hypoglycaemia to the beginning of treatment. Treatment delay for SLS was always less than 5 minutes and was not recorded precisely so 5 minutes was taken as a conservative estimate; for IVG, treatment delay was the observed value. |
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Graz et al. Malaria Journal 2008 7:242 doi:10.1186/1475-2875-7-242 |
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