Table 2 |
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|
Mean percentage of lymphocyte subsets at presentation with acute non-complicated malaria, 4 weeks post-recovery and in healthy age-matched controls |
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| Acute (A) |
Recovery (R) |
Controls (C) |
Significance |
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|
|
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Cell type |
mean (SEM) percent |
mean (SEM) percent |
mean (SEM) percent |
A vs.R |
A vs.C |
R vs.C |
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|
|
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| CD3+CD45+ |
56.9 |
(2.4) |
54.3 |
(2.3) |
52.7 |
(2.7) |
0.37 |
0.27 |
0.67 |
| CD19+CD45+ |
21.4 |
(2.1) |
26.1 |
(1.7) |
23.5 |
(2.8) |
0.02 |
0.53 |
0.41 |
| CD4+CD3+ |
34.8 |
(2.6) |
36.0 |
(2.2) |
29.4 |
(1.9) |
0.64 |
0.14 |
0.04 |
| CD8+CD3+ |
16.0 |
(2.5) |
12.8 |
(1.2) |
18.2 |
(0.8) |
0.22 |
0.62 |
0.03 |
|
|
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| Naive 1 CD38-IgD+CD19+ |
23.7 |
(2.9) |
29.3 |
(4.2) |
38.2 |
(3.4) |
0.03 |
0.00 |
0.12 |
| Naive 2 CD38+IgD+CD19+ |
39.7 |
(3.8) |
44.7 |
(4.4) |
27.2 |
(4.4) |
0.11 |
0.04 |
0.01 |
| Memory 3 CD38+IgD-CD19+ |
22.7 |
(2.4) |
14.4 |
(1.3) |
14.2 |
(1.1) |
0.00 |
0.01 |
0.91 |
| Memory 4 CD38-IgD-CD19+ |
13.5 |
(1.4) |
11.7 |
(1.3) |
22.8 |
(2.6) |
0.11 |
0.01 |
0.00 |
|
|
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| CD10+CD19+ |
24.6 |
(2.5) |
29.0 |
(2.7) |
21.2 |
(1.8) |
0.04 |
0.31 |
0.04 |
|
|
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|
Sample size (n) was n = 15 for all Acute & Recovery outcomes except CD19+CD10+ (n = 12), and all Memory and Naive outcomes (n = 11). N = 11 for controls except for CD4 (n = 10), CD19+CD10+ (n = 9), CD19+CD27+ (n = 7), and CD8 (n = 5). Heterogeneity of variance assumptions were tested by the Levene statistic, and heterogeneous t-tests were utilized as needed. Significant differences are in bold. |
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|
Asito et al. Malaria Journal 2008 7:238 doi:10.1186/1475-2875-7-238 |
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