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A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya

Petra F Mens*, Patrick Sawa, Sandra M van Amsterdam, Inge Versteeg, Sabah A Omar, Henk DFH Schallig and Piet A Kager

Malaria Journal 2008, 7:237 doi:10.1186/1475-2875-7-237

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A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania

Seif A Shekalaghe, Chris Drakeley, Sven van den Bosch, Roel ter Braak, Wouter van den Bijllaardt, Charles Mwanziva, Salimu Semvua, Alutu Masokoto, Frank Mosha, Karina Teelen, Rob Hermsen, Lucy Okell, Roly Gosling, Robert Sauerwein, Teun Bousema Malaria Journal 2011, 10:247 (24 August 2011)

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This study illustrates the possibility to achieve high coverage with a three-day MDA intervention, but also the difficulty in defining suitable outcome measures to evaluate interventions in areas of very low malaria transmission intensity.

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Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa

William Yavo, Babacar Faye, Thomas Kuete, Vincent Djohan, Serge A Oga, Richard R Kassi, Mariama Diatta, Moor V Ama, Roger Tine, Jean-Louis Ndiaye, Jean-Bedel Evi, Albert Same-Ekobo, Oumar Faye, Moussa Koné Malaria Journal 2011, 10:198 (20 July 2011)

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In this study performed in three Afican countries, dihydroartemisinin-piperaquine was as effective and well-tolerated as artemether-lumefantrine in the treatment of uncomplicated falciparum malaria. In addition, dihydroartemisinin-piperaquine, a single daily dose, could be at an advantage over artemether-lumefantrine because of better treatment observance.

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Changing malaria intervention coverage, transmission and hospitalization in Kenya

Emelda A Okiro, Victor A Alegana, Abdisalan M Noor, Robert W Snow Malaria Journal 2010, 9:285 (15 October 2010)

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Description of the changes in malaria epidemiology in Kenya by looking at the changes in malaria admission in eight hospitals and in several explanatory variables, such as ITN coverage. This work brings additional information to the current debate over the “epidemiological transition” of malaria in sub-Saharan Africa.

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Coartem®: the journey to the clinic

Zulfiqarali G Premji Malaria Journal 2009, 8(Suppl 1):S3 (12 October 2009)

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