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Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria

Charles Mwanziva, Seif Shekalaghe, Arnold Ndaro, Bianca Mengerink, Simon Megiroo, Frank Mosha, Robert Sauerwein, Chris Drakeley, Roly Gosling and Teun Bousema*

Malaria Journal 2008, 7:232 doi:10.1186/1475-2875-7-232

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A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania

Seif A Shekalaghe, Chris Drakeley, Sven van den Bosch, Roel ter Braak, Wouter van den Bijllaardt, Charles Mwanziva, Salimu Semvua, Alutu Masokoto, Frank Mosha, Karina Teelen, Rob Hermsen, Lucy Okell, Roly Gosling, Robert Sauerwein, Teun Bousema Malaria Journal 2011, 10:247 (24 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study illustrates the possibility to achieve high coverage with a three-day MDA intervention, but also the difficulty in defining suitable outcome measures to evaluate interventions in areas of very low malaria transmission intensity.

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