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Trial participants, interventions and outcomes |
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| Reference |
Participants |
Interventions (drugs, route of administration and treatment duration) |
Outcomes |
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| [8] |
54 children aged 1 to 5 years in Nigeria |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time, 28th day cure rate, adverse effects & neurological sequelae |
| (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days. This was changed to oral dose when patient was able to drink |
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| [9] |
160 children aged 5 month to 12 years in Kenya |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 2 days. One dose of SP was given after parasite clearance. |
Mortality, parasite clearance time, fever clearance time, coma resolution time, adverse effects & neurological sequelae |
| (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for at least 3 days. Then one dose of SP was given after parasites clearance and when the patient was able to drink |
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| [10] |
576 children aged 1 to 9 years in Gambia |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 3 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time, 28th day cure rate, adverse effects & neurological sequelae |
| (2) IM Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 5 days. This was changed to oral dose when the patient was able to drink |
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| [11] |
72 children aged 3 months to 14 years in Vietnam |
(1) IM Artesunate 3 mg/kg initially and 2 mg/kg at 12, 24,48 and 72 hrs, followed by oral mefloquine 15 mg/kg at 96 hours |
Mortality, parasite clearance time, fever clearance time, coma resolution time, duration of hospital stay, adverse effects & neurological sequelae |
| (2) IM Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, followed by single dose of pyrimethamine/sulfadoxine on day 7 |
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| [12] |
164 children in Malawi (age range not stated) |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time, coma resolution time, 28th day cure rate, adverse effects & neurological sequelae |
| (2) IV Quinine(20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [13] |
37 children in Nigeria (age range not stated) |
(1) IM Artemether 3.2 mg/kg starting dose, then 1.6 mg/kg 12 hours later, then 1.6 mg/kg per day for 2 days |
Mortality, percentage of children with parasites clearance at day 7, fever clearance time, coma resolution time & neurologic sequelae |
| (2) IV Quinine 10 mg/kg initial dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [14] |
103 children aged 1 to 5 years in Nigeria |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time, 28th day cure rate & neurological sequelae |
| (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [15] |
92 children aged 0–10 years in Zambia |
(1) IM β-Arteether 3.2 mg/kg in the first day, then 1.6 mg/kg for next 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time, adverse effects & neurological sequelae |
| (2) IV Quinine (20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [16] |
102 children aged 0–10 years in Cameroon |
(1) IM β-Arteether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time, adverse effects, 28th cure rate & neurological sequelae |
| (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [17] |
41 children in Sudan (age range not stated) |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for t 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time & adverse effects |
| (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [18] |
77 children aged 3 months to 15 years in Sudan |
(1) IM Artemether 1.6 mg/kg, repeated after 12 hrs, then daily for 4 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time & 28th day cure rate |
| (2) IV Quinine 10 mg/kg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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| [19] |
46 children aged 0–14 years from India |
(1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 5 days |
Mortality, parasite clearance time, fever clearance time, coma resolution time & adverse effects |
| (2) IV Quinine (20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink |
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PrayGod et al. Malaria Journal 2008 7:210 doi:10.1186/1475-2875-7-210 |
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