Malaria Journal

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Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands

Tarekegn A Abeku*, Mojca Kristan, Caroline Jones, James Beard, Dirk H Mueller, Michael Okia, Beth Rapuoda, Brian Greenwood and Jonathan Cox

Malaria Journal 2008, 7:202 doi:10.1186/1475-2875-7-202

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Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance

Louise Marquart, Alice Butterworth, James S McCarthy, Michelle L Gatton Malaria Journal 2012, 11:74 (19 March 2012)

The results of the model indicate that good quality RDTs should be able to detect parasites on the first day of symptoms, and that the persistence of the antigen will cause the tests to remain positive for at least seven days after treatment.

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Reducing malaria misdiagnosis: the importance of correctly interpreting Paracheck Pf® "faint test bands" in a low transmission area of Tanzania

Lisa K Allen, Jennifer M Hatfield, Giselle DeVetten, Jeremy C Ho, Mange Manyama BMC Infectious Diseases 2011, 11:308 (3 November 2011)

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Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania

Deus S Ishengoma, Filbert Francis, Bruno P Mmbando, John PA Lusingu, Pamela Magistrado, Michael Alifrangis, Thor G Theander, Ib C Bygbjerg, Martha M Lemnge Malaria Journal 2011, 10:176 (26 June 2011)

This paper examines the sensitivity and specificity of RDT versus microscopy in two different types of study – a longitudinal study of febrile illness and a community cross sectional in Tanzania. The authors show that RDT reduced the number of malaria treatments given, but question the sensitivity of the tests.