Table 5

IgG subclass levels separated by FcγRIIa R131H genotypes and alleles in the Fulani and Dogon ethnic groups

Dogon
 Fulani


no.
 age
 IgG1
 IgG2
 IgG3
 IgG4
 no.
 age
 IgG1
 IgG2
 IgG3
 IgG4

H/H
 24
 15
 15 ± 2.9
 0.4 ± 5.6
 4.5 ± 3.5
 0.54 ± 2.0
 39
 15
 34 ± 4.4
 5.9 ± 11
 6.3 ± 2.5
 0.29 ± 7.8
H/R
 69
 16
 17 ± 3.9
 1.2 ± 6.7
 3.8 ± 2.6
 2.3 ± 2.3
 68
 23
 38 ± 3.7
 7.5 ± 9.1
 12 ± 2.8
 1.8 ± 2.6
R/R
 64
 20
 24 ± 3.5
 1.5 ± 8.1
 6.2 ± 2.9
 0.41 ± 2.9
 36
 21
 24 ± 3.4
 2.4 ± 9.8
 9.5 ± 2.9
 0.42 ± 2.3
p-valuea
0.07
 0.2
 0.02
 0.03
 0.5
0.07
 0.2
 0.05
 0.01
 0.04
R-allele carriers
 133
 18
 20 ± 3.7
 1.3 ± 7.3
 4.8 ± 2.8
 0.43 ± 2.5
 93
 22
 33 ± 3.6
 5.0 ± 10
 11 ± 2.8
 0.5 ± 2.5
p-valueb
0.3
 0.4
 0.007
 0.8
 0.2
0.03
 0.08
 0.1
 0.009
 0.4
H-allele carriers
 104
 22
 17 ± 3.6
 0.89 ± 6.7
 3.9 ± 2.8
 0.46 ± 2.3
 107
 20
 37 ± 3.9
 6.8 ± 9.5
 9.4 ± 2.8
 0.44 ± 4.4
p-valuec
0.02
 0.9
 0.7
 0.004
 0.02
0.9
 0.09
 0.02
 0.9
 0.8

The results are expressed in ELISA units and presented as geometric means ± SD.

a Statistical analysis of differences in IgG subclass levels between the different genotypes tested with ANOVA

b Statistical analysis of differences in IgG subclass levels between the R-allele carriers and HH homozygotes Mann-Whitney.

c Statistical analysis of differences in IgG subclass levels between the H-allele carriers and RR homozygotes by Mann-Whitney.

Israelsson et al. Malaria Journal 2008 7:175   doi:10.1186/1475-2875-7-175

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