Table 3

Adult and child IgG response profile as compared with clinical data during longitudinal follow-up.

IgG response profile category
 # with clinical information complete
 % in each response category
 # with febrile illness
 % with febrile illness
 GMP (95% CI)
Adult
 Pre-Positive
 22
 48.9%
 4
 18.2%
 19
 (6–60)

Infection-Positive
 18
 40.0%
 9
 50.0%
 78
 (37–164)

Late-Positive
 1
 2.2%
 0
 0
 16
 n/a

Non-responder
 4
 8.9%
 3
 75.0%
 156
 (12–2027)
Child
 Pre-Positive
 6
 18.2%
 1
 16.7%
 8
 (1–53)

Infection-Positive
 16
 48.5%
 12
 75.0%
 284
 (121–669)

Late-Positive
 4
 12.1%
 4
 100.0%
 1210
 (754–1941)

Non-responder
 7
 21.2%
 6
 85.7%
 120
 (26–561)

Adult and child IgG response profile was compared with febrile illness (patient-reported history or measured by physician within one week of infection) and parasite density, where infections were detected during one of 4 weekly active sampling visits. A pre-positive response, most frequently observed in adults, was associated with less febrile illness (χ2, p = 0.0056) and lower parasite density (WRS, p = 0.0005).

Torres et al. Malaria Journal 2008 7:173   doi:10.1186/1475-2875-7-173

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