Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission
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* Corresponding author: OraLee H Branch obranch@uab.edu
Malaria Journal 2008, 7:173 doi:10.1186/1475-2875-7-173
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Review
The complexities of malaria disease manifestations with a focus on asymptomatic malaria Dolie D Laishram, Patrick L Sutton, Nutan Nanda, Vijay L Sharma, Ranbir C Sobti, Jane M Carlton, Hema Joshi Malaria Journal 2012, 11:29 (31 January 2012) The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe malaria, to mild and uncomplicated, to asymptomatic infections. Asymptomatic malaria remains a major challenge for malaria control programmes.
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Research
Patrick L Sutton, Eva H Clark, Claudia Silva, OraLee H Branch Malaria Journal 2010, 9:3 (4 January 2010) The authors point out that vaccine development must overcome strain-specific responses and they offer interesting data from the Peruvian Amazon on the development of diversity in an area that had eliminated malaria for 30 years before it re-emerged.
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Research
Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan Adults Arlene E Dent, Kiprotich Chelimo, Peter O Sumba, Michele D Spring, Brendan S Crabb, Ann M Moormann, Daniel J Tisch, James W Kazura Malaria Journal 2009, 8:162 (16 July 2009) A very useful study quantifying the stability
of immunological responses to MSP-1 over time, which will inform the design and analysis of studies to investigate immunity in the field.
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