Table 2 |
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|
Infection prevalence and MOI in subjects stratified by blood groups and haemoglobinopathies before and after the transmission season |
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|
June 2002 |
January 2003 |
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|
|
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|
Whole groupa n (%) |
nb (%) |
MOI; mean (range) |
nb (%) |
MOI; mean (range) |
|
|
|
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|
Blood group |
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|
O |
193 (52) |
81/193 (42) |
2.6 (1 – 7) |
99/193 (51) |
4.1 (1–10)g*** |
|
A |
100 (27) |
47/100 (47) |
2.6 (1 – 7) |
50/100 (50) |
4.0 (1 – 9)g** |
|
B |
69 (18) |
34/69 (49) |
2.3 (1 – 6) |
32/69 (46) |
4.2 (1 – 10)g* |
|
AB |
10 (3) |
2/10 (20) |
4.0 (1 – 7) |
7/10 (70) |
4.6 (2 – 8)g* |
|
Hemoglobin |
|||||
|
AA |
319 (86) |
144/319 (45) |
2.5 (1 – 7) |
162/319 (51) |
4.0 (1–10)g*** |
|
AS |
51 (14) |
19/51 (37) |
2.7 (1 – 5) |
26/51 (51) |
4.5 (1 – 10)g** |
|
α+-thalassemiaC |
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|
Normal |
234 (76) |
103/234 (44) |
2.3 (1 – 7) |
118/234 (50) |
3.9 (1–10)g*** |
|
Mutation |
75 (24) |
37/75 (49) |
2.8 (1 – 7) |
36/75 (48) |
4.1 (1 – 9) |
|
G6PD in femalesd |
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|
Normal |
141 (81) |
60/141 (43) |
2.7 (1 – 7) |
73/141 (52)f |
4.4 (1 – 10)g** |
|
Mutation |
34 (19) |
11/34 (32) |
2.7 (1 – 4) |
9/34 (26) |
4.6 (1 – 10) |
|
G6PD in malese |
|||||
|
Normal |
166 (87) |
77/166 (46) |
2.5 (1 – 7) |
90/166 (54) |
3.8 (1–10)g*** |
|
Mutation |
24 (13) |
14/24 (58) |
1.7 (1 – 4) |
14/24 (58) |
3.4 (1 – 7) |
|
|
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|
a Total number of samples = 372, missing values for hemoglobin (n = 2), α+-thalassemia (n = 63) and G6PD (n = 7). b Proportion of infected individuals to total. c Mutation indicated in both heterozygous and homozygous state. d G6PD mutations include G6PD A-/B, A-/A heterozygous and A-/A- homozygous genotypes. e G6PD mutation corresponds to A- hemizygous genotype. f Significantly less infection prevalence in G6PD mutated girls as compared to normal ones; χ2-test, P < 0.01. g Wilcoxon signed rank test for the comparison of MOI in June and January; * P < 0.05 ** P < 0.01 *** P < 0.0001 |
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|
Vafa et al. Malaria Journal 2008 7:17 doi:10.1186/1475-2875-7-17 |
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