Table 6

Risk factors for a male-biased gametocyte sex ratio 7 days after amodiaquine treatment of children with uncomplicated falciparum malaria, showing the crude and adjusted odd ratios (OR) and their 95% confidence intervals (CI)
Variables
 Total Number
 No with gsr ≥ 0.5
 OR (95% CI)
 P value
 AOR (95% CI)
 P value
Gender





     male
 25
 7
 1


     female
 25
 8
 1.1 (0.6 – 2)
 0.75
 -
 -







Age





     < 5 years
 20
 7
 1


     ≥ 5 years
 30
 8
 0.8 (0.5 – 1.4)
 0.5
 -
 -







Duration of illness





     ≤ 3 days
 38
 12
 1


     > 3 days
 12
 3
 0.8 (0.2 – 2.5)
 0.67
 -
 -







Fever*





     afebrile
 21
 6
 1


     febrile
 29
 9
 1.1 (0.6 – 1.7)
 0.85
 -
 -







PCV (day 0)





     < 25%
 6
 5
 1
1
     ≥ 25%
 44
 10
 0.6 (0.5 – 1)
 0.002
 0.06 (0.006 – 0.7)
 0.03







Parasitaemia (day 0)





     ≤ 20,000 μl/l
 22
 3
 1
1
     > 20,000 μl/l
 28
 12
 1.8 (1.1 – 2.7)
 0.025
 5.7 (1 – 33)
 0.05







Gametocytaemia (day 0)





     < 18 μl/l
 11
 4
 1


     ≥ 18 μl/l
 17
 7
 1.1 (0.6 – 2)
 0.8
 -
 -







Year





     pre 2006
 34
 8
 1


     2006
 16
 7
 1.8 (0.8 – 4)
 0.15
 -
 -







GSR (day 0)





     < 0.5
 26
 10
 1


     ≥ 0.5
 2
 1
 1.5 (0.1 – 22)
 0.75
 -
 -







FCT





     < 2 days
 33
 10
 1


     ≥ 2 days
 2
 1
 2.2 (0.1 – 32)
 0.56
 -
 -







PCT





     < 3 days
 32
 8
 1


     ≥ 3 days
 18
 7
 1.5 (0.7 – 3.1)
 0.3
 -
 -







PCV (day 7)





     < 25%
 4
 3
 1
1
     ≥ 25%
 46
 12
 0.8 (0.6 – 3.7)
 0.04
 0.06 (0.003 – 1)
 0.05







Re-parasitaemia





     Absent
 44
 14
 1


     Present
 6
 1
 0.5 (0.06 – 3.7)
 0.45
 -
 -

*Fever, body temperature ≥ 37.5°C; FCT, fever clearance time; GSR, gsr, gametocyte sex ratio; PCV, packed cell volume; PCT, parasite clearance time

Sowunmi et al. Malaria Journal 2008 7:169   doi:10.1186/1475-2875-7-169

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