Figure 1.

HZ and trophozoite phagocytosis enhances IL1-beta production by human adherent monocytes. Human adherent monocytes were unfed or fed with HZ, trophozoites and control meals (IgG-anti D-opsonized nonparasitized RBCs, latex particles). After 3 h phagocytosis and a further incubation during 48 h, IL1-beta levels were measured by ELISA in cell supernatants. Data are given as ng IL-1beta/ml supernatant (mean values ± SD of six independent experiments). Data were analysed for significance by Student's t-test. Significance of differences (column numbers): trophozoite-fed(3)/HZ-fed(5) vs unfed-(1)/nonparasitized RBC-fed(2) monocytes, p < 0.05; latex-fed(4) vs unfed-(1)/nonparasitized RBC-fed(2) monocytes, n.s.; trophozoite-fed(3) vs HZ-fed(5) monocytes, n.s.