Table 2 |
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|
Association of serum IgG levels to recombinant domains of PfEMP1 with clinical malaria in Chonyi, Kenya for the period October 2000 until March 2001 |
|||
| Chonyi |
Slide all |
n = 596 |
|
|
|
|||
| Antigen |
Odds Ratio |
p-value |
95% C. I. |
|
|
|||
| DBL1α |
0.75 |
0.580 |
0.26 – 2.11 |
| DBL2β |
0.63 |
0.472 |
0.18 – 2.21 |
| CIDR1α |
0.71 |
0.365 |
0.33 – 1.50 |
| DBL4γ |
0.89 |
0.791 |
0.37 – 2.13 |
| DBL5β |
0.72 |
0.517 |
0.26 – 1.95 |
|
|
|||
| Chonyi |
Slide positive |
n = 197 |
|
|
|
|||
| Antigen |
Odds Ratio |
p-value |
95% C. I. |
|
|
|||
| DBL1α |
0.75 |
0.580 |
0.26 – 2.11 |
| DBL2β |
0.63 |
0.472 |
0.18 – 2.21 |
| CIDR1α |
0.71 |
0.365 |
0.33 – 1.50 |
| DBL4γ |
0.89 |
0.791 |
0.37 – 2.13 |
| DBL5β |
0.72 |
0.517 |
0.26 – 1.95 |
|
|
|||
| Chonyi |
Slide negative |
n = 399 |
|
|
|
|||
| Antigen |
Odds Ratio |
p-value |
95% C. I. |
|
|
|||
| DBL1α |
0.05 |
0.020 |
0.04 – 0.63 |
| DBL2β |
0.26 |
0.208 |
0.32 – 2.10 |
| CIDR1α |
0.72 |
0.553 |
0.25 – 2.10 |
| DBL4γ |
0.49 |
0.290 |
0.14 – 1.81 |
| DBL5β |
0.49 |
0.343 |
0.11 – 2.11 |
|
|
|||
|
1Results from a multiple logistic regression giving the odds ratio for becoming a case of clinical malaria in the subsequent six months if scored as antibody positive against each domain in turn controlling for for age (categorized as a factor of six months duration) and exposure (estimated by responses to whole schizont extract). An individual was deemed antibody positive if the OD obtained was greater than the mean OD plus 3 standard deviations obtained from a panel of non-exposed donors. |
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|
Mackintosh et al. Malaria Journal 2008 7:155 doi:10.1186/1475-2875-7-155 |
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