Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children
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* Corresponding author: Elizabeth A Ashley elizabeth.ashley@epicentre.msf.org
Malaria Journal 2008, 7:154 doi:10.1186/1475-2875-7-154
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Julien Zwang, Piero Olliaro, Hubert Barennes, Maryline Bonnet, Philippe Brasseur, Hasifa Bukirwa, Sandra Cohuet, Umberto D'Alessandro, Abdulaye Djimdé, Corine Karema, Jean-Paul Guthmann, Sally Hamour, Jean-Louis Ndiaye, Andreas Mårtensson, Claude Rwagacondo, Issaka Sagara, Albert Same-Ekobo, Sodiomon B Sirima, Ingrid van den Broek, Adoke Yeka, Walter RJ Taylor, Grant Dorsey, Milijaona Randrianarivelojosia Malaria Journal 2009, 8:203 (23 August 2009) This multi-center analysis study addresses efficacy of artesunate-amodiaquine, a very important candidate for the treatment of uncomplicated malaria globally. The analysis of patient-level data examining the efficacy of AS&AQ compared to local standard therapy, makes a strong case for the use of AS&AQ in all transmission settings.
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Research
The effect of varying analytical methods on estimates of anti-malarial clinical efficacy Wendy J Verret, Grant Dorsey, Francois Nosten, Ric N Price Malaria Journal 2009, 8:77 (22 April 2009) Anti-malarial drug clinical trials are conducted both to monitor anti-malarial drug resistance and to compare treatment regimens. Estimates of anti-malarial clinical efficacy vary significantly depending on the analytical methodology from which they are derived. This paper compares different ways to estimate the risk of failure in 65 treatment arms from 29 clinical trials.
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