Inbred/outbred fitness ratios (FR) of populations with a high α+-thalassemia frequency over ten generations. At the start of simulation, the frequency of α+-thalassemia is 0.5. The black lines are trends for the first, fifth and tenth generation. FR > 1 is seen in every generation for all 0 <F < 0.05. This graph demonstrates robustness of inbreeding elevation found at all levels of inbreeding which were observed in human field studies, i.e., 0 <F ≤ 0.045 [13,14].
Denic et al. Malaria Journal 2008 7:150 doi:10.1186/1475-2875-7-150