The relative excess of α+-thalassemia allele frequency (red bars) and population size (blue bars) per generation in an inbred population when compared with a non-inbred population. The survivals (S) of the three genotypes used in this simulation are shown in the lower part of graph at the intersections with vertical lines which point to the results in the upper part of graph. The ratio of differential survival of genotypes = (S-α/-α - S-α/αα)/(S-α/αα - Sαα/αα).
Denic et al. Malaria Journal 2008 7:150 doi:10.1186/1475-2875-7-150