Table 4

Sensitivity analyses on the estimated relative increase in Plasmodium falciparum parasite biomass due to HIV-1, sub Saharan Africa*

Relative increase parasite

biomass

Best estimate (95% CI)*

18.0%(11.6–26.9)

Parameters

Lower-bound assumption

Upper-bound assumption

Lower-bound assumption

Upper-bound assumption

HIV prevalence (UNAIDS country point estimate)

lower-bound

higher-bound

11.4%

23.8%

Relative risk of incidence of uncomplicated symptomatic malaria, in HIV-infected individuals with CD4<200/μl and CD4 200–499 compared to HIV-negatives

4/2

6/4

15.8%

19.4%

Relative parasite density during uncomplicated symptomatic malaria, in HIV-infected patients with CD4<200/μl and CD4 200–499/μL compared to HIV-uninfected patients

2/1

4/2

15.5%

19.9%

Relative risk of progression to severe malaria, in HIV-infected individuals with CD4<200/μl and CD4 200–499/μL compared to HIV-uninfected patients

8/3

24/12

17.2%

18.6%

Relative parasite density during severe malaria, in HIV-infected patients with CD4<500/μl compared to HIV-uninfected patients

0.5/0.5

2.0/2.0

16.9%

18.2%

Assume no HIV-1 impact on incidence of symptomatic malaria, severe malaria or parasite density in children under 15 years

17.6%

n.a.

Mean parasite density during uncomplicated symptomatic malaria in HIV-negative patients equal for all age groups and endemicities: 20000/μL

n.a.

17.2%

* For default values underlying this best estimate, see Table 2.

Van geertruyden et al. Malaria Journal 2008 7:134   doi:10.1186/1475-2875-7-134