Monitoring antimalarial safety and tolerability in clinical trials: A case study from Uganda
-
* Corresponding author: Sarah G Staedke sarah.staedke@lshtm.ac.uk
Malaria Journal 2008, 7:107 doi:10.1186/1475-2875-7-107
Accesses
- Last 30 days: 28 accesses
- Last year: 459 accesses
- All time: 3147 accesses
Cited by
BioMed Central: 3 citations
|
Research
Quique Bassat, Raquel Gonzalez, Sonia Machevo, Alain Nahum, John Lyimo, Hamma Maiga, Andreas Martensson, Mahfudh Bashraheil, Peter Ouma, David Ubben, Verena Walter, Obiyo Nwaiwu, Chemtai Kipkeu, Gilbert Lefevre, Bernhards Ogutu, Clara Menendez Malaria Journal 2011, 10:369 (16 December 2011) The study investigates the impact of different weight bands on treatment outcome after AL treatment. There has been some concern that the dosing optimization according weight bands may result in over dosing young children and under dosing older children. Therefore this study and the findings are very important for malaria endemic countries that have adopted AL as the first-line regimen.
|
|
Research
Shereen Katrak, Anne Gasasira, Emmanuel Arinaitwe, Abel Kakuru, Humphrey Wanzira, Victor Bigira, Taylor G Sandison, Jaco Homsy, Jordan W Tappero, Moses R Kamya, Grant Dorsey Malaria Journal 2009, 8:272 (30 November 2009) While ACT is rapidly becoming the standard of care for uncomplicated malaria in most of Africa, there is limited data on the safety and tolerability of these drugs, especially in young children and patients co-infected with HIV.
|
|
Methodology
Muhammad Ntale, Celestino Obua, Jackson Mukonzo, Margarita Mahindi, Lars L Gustafsson, Olof Beck, Jasper W Ogwal-Okeng Malaria Journal 2009, 8:52 (30 March 2009) The authors report on a sampling method for quantifying concentrations of amodiaquine and its active metabolite, desethylamodiaquine from small volume, whole blood samples spotted onto filter paper. This methodology increases the feasibility of collecting pharmacokinetic samples in remote field sites and from young children.
|