Articles
Volume 6 (2007) - October 2007
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Research
The effect of HIV on morbidity and mortality in children with severe malarial anaemia Samuel Malamba, Wolfgang Hladik, Arthur Reingold, Flora Banage, Willi McFarland, George Rutherford, Derrick Mimbe, Esau Nzaro, Robert Downing, Jonathan Mermin Malaria Journal 2007, 6:143 (31 October 2007) This study demonstrates that HIV-infected children were approximately three times more likely to die within seven days of a symptomatic malaria episode than HIV-uninfected children, and had more frequent re-admissions due to malaria within 28 days.
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Research
Sonia LR Casimiro, Janet Hemingway, Brian L Sharp, Michael Coleman Malaria Journal 2007, 6:142 (31 October 2007) The development of insecticide resistance is a potential threat to any insecticide-based malaria vector control programme. The re-introduction of DDT into Mozambique’s IRS programme in 2005 poses interesting questions. Is monitoring insecticide resistance feasible for a malaria control programme and what the impact of monitoring would this have on policy ?
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Research
Jorge Cano, Pedro Berzosa, Aida de Lucio, Miguel Descalzo, Leonardo Bobuakasi, Sisinio Nzambo, Melchor Ondo, Jesus N Buatiche, Gloria Nseng, Agustin Benito Malaria Journal 2007, 6:141 (25 October 2007) Based on the high degree of geographical isolation of the Annobon population and the apparent marked seasonality of the transmission, it is conceivqble that malaria could be eliminated from this small African island.
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Research
Evaluation of the intra- and inter-specific genetic variability of Arthur M Talman, Linda Duval, Eric Legrand, Véronique Hubert, Seiha Yen, David Bell, Jacques Le Bras, Frédéric Ariey, Sandrine Houze Malaria Journal 2007, 6:140 (25 October 2007) Intra-specific genetic variability is not a significant factor in the variation of efficiency observed in RDTs in the detection of malaria parasites. pLDH offers advantages as a target antigen for diagnosis. The identification of pan-specific and species-specific regions may help in development of more sensitive and specific monoclonal antibodies for MRDTs.
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Research
Jennifer CC Hume, Mark Tunnicliff, Lisa C Ranford-Cartwright, Karen P Day Malaria Journal 2007, 6:139 (24 October 2007) By assessing the susceptibility of different mosquitoes to different tropical isolates of pqrqsites, the authors addressed two important questions: whether the differentiated structure of Plasmodium falciparum populations results solely from geographical separation or whether the mosquito vector contributes to this population separation, and whether parasite-vector compatibility/incompatibility may impact on the spread of drug resistance between parasite populations.
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Research
Mannitol as adjunct therapy for childhood cerebral malaria in Uganda: A randomized clinical trial Beatrice Namutangula, Grace Ndeezi, Justus S Byarugaba, James K Tumwine Malaria Journal 2007, 6:138 (24 October 2007) This study addresses an important question in cerebral malaria: is mannitol effective adjunctive treatment for cerebral malaria? It is the first randomized, double-blinded, placebo-controlled study to address this question.
Although this cannot be considered a definitive study (for example, lack of crucial information about intracranial pressure) there is much to be learned from this study, because the study reflects conditions of actual practice in an African referral hospital.
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Research
Genetic population structure of Marta Moreno, Patricia Salgueiro, José Vicente, Jorge Cano, Pedro J Berzosa, Aida de Lucio, Frederic Simard, Adalgisa Caccone, Virgilio E Do Rosario, João Pinto, Agustín Benito Malaria Journal 2007, 6:137 (15 October 2007) |
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Research
Role of information and communication networks in malaria survival Pallab Mozumder, Achla Marathe Malaria Journal 2007, 6:136 (10 October 2007) The results suggest that information and communication networks can substantially scale up the effectiveness of the existing resources for malaria prevention.
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Research
George Jiang, Yupin Charoenvit, Alberto Moreno, Maria F Baraceros, Glenna Banania, Nancy Richie, Steve Abot, Harini Ganeshan, Victoria Fallarme, Noelle B Patterson, Andrew Geall, Walter R Weiss, Elizabeth Strobert, Ivette Caro-Aquilar, David E Lanar, Allan Saul, Laura B Martin, Kalpana Gowda, Craig R Morrissette, David C Kaslow, Daniel J Carucci, Mary R Galinski, Denise L Doolan Malaria Journal 2007, 6:135 (9 October 2007) The concept of a multi-component malaria vaccine that induces protective immune responses against liver and blood stages is a sound one and likely to be necessary for production of a vaccine of high efficacy.
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Case study
Heidi Hopkins, Ambrose Talisuna, Christopher JM Whitty, Sarah G Staedke Malaria Journal 2007, 6:134 (8 October 2007) Home-based management of malaria, which involves presumptively treating febrile children with pre-packaged antimalarial drugs distributed by members of the community, is promoted as a major strategy to improve prompt delivery of effective malaria treatment in Africa. Of 1,069 potentially relevant publications identified, only six studies were identified as meeting inclusion criteria. Heterogeneity of the evaluations, including variability in study design, precluded meta-analysis and overall results were mixed.
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Methodology
PCR-based karyotyping of Mamadou B Coulibaly, Marco Pombi, Beniamino Caputo, Davis Nwakanma, Musa Jawara, Lassana Konate, Ibrahima Dia, Abdrahamane Fofana, Marcia Kern, Frédéric Simard, David J Conway, Vincenzo Petrarca, Alessandra Torre, Sékou Traoré, Nora J Besansky Malaria Journal 2007, 6:133 (1 October 2007) A PCR assay for molecular karyotyping was developed based on sequences at the breakpoint junctions. This rapid tool for identifying the BAMAKO form across developmental stages and sexes and opens new perspectives for the study of mosquito ecology and behaviour.
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