Articles
Volume 6 (2007) - November 2007
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Research
Multiple host-switching of Haemosporidia parasites in bats Linda Duval, Vincent Robert, Gabor Csorba, Alexandre Hassanin, Milijaona Randrianarivelojosia, Joe Walston, Thy Nhim, Steve M Goodman, Frédéric Ariey Malaria Journal 2007, 6:157 (29 November 2007) Understanding parasites of bats has a broad significance to the study of a potential emergence of infectious disease in humans; in addition, studies of haemosporida in bats are rare and these are the first molecular data available. The geographical location of the study in Madagascar and Cambodia, two areas of considerable animal biodiversity, is also noteworthy.
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Methodology
Michel Vaillant, Piero Olliaro Malaria Journal 2007, 6:156 (26 November 2007) A new method of calculation for comparing in vitro antimalarial drugs IC50s and monitor changes in drug susceptibility
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Methodology
Chris Bass, Martin S Williamson, Craig S Wilding, Martin J Donnelly, Linda M Field Malaria Journal 2007, 6:155 (22 November 2007) This paper describes an improved method for accurate molecular identification of specimens of the An. gambiae species complex
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Research
Sheena Garg, Mohammad T Alam, Manoj K Das, Vas Dev, Ashwani Kumar, Aditya P Dash, Yagya D Sharma Malaria Journal 2007, 6:154 (22 November 2007) |
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Research
Anders Enevold, Watoky MMM Nkya, Michael Theisen, Lasse S Vestergaard, Anja TR Jensen, Trine Staalsoe, Thor G Theander, Ib C Bygbjerg, Michael Alifrangis Malaria Journal 2007, 6:153 (16 November 2007) In this study the authors investigated the role and the prevalence of anti-malarial antibodies in relation to treatment failure. The findings show that the acquired immunity can enhance the clinical efficacy of drug therapy and that levels of anti-GLURP antibodies were strongly associated with treatment outcome.
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Case study
Jean Ndiaye, Roger C Tine, Babacar Faye, El Hadj Dieye, Pape Diack, Valérie Lameyre, Oumar Gaye, Husseyn Sow Malaria Journal 2007, 6:152 (15 November 2007) Description of an emergency paediatric kit which can be used for the management of malaria by community-based health workers for children who cannot be treated orally.
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Research
The decline in paediatric malaria admissions on the coast of Kenya Emelda A Okiro, Simon I Hay, Priscilla W Gikandi, Shahnaaz K Sharif, Abdisalan M Noor, Norbert Peshu, Kevin Marsh, Robert W Snow Malaria Journal 2007, 6:151 (15 November 2007) The paper describes presents an interesting description of data that attempt to show a correlation between declining pediatric malaria admissions in three districts in coastal Kenya and increased measures for the prevention of malaria
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Research
Philippe Brasseur, Patrice Agnamey, Oumar Gaye, Michel Vaillant, Walter RJ Taylor, Piero L Olliaro Malaria Journal 2007, 6:150 (15 November 2007) There have been few studies looking at the long-term use of AS+AQ in Africa. The favourable results of this study support the policy decision of using this combination in Senegal. After six years of use, it is still highly effective in the Oussouye district, where the rate of in vitro chloroquine resistance is > 60%
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Research
Jennifer Luchavez, Ma Eichelle Lintag, Mary Coll-Black, Fred Baik, David Bell Malaria Journal 2007, 6:149 (15 November 2007) Four blood collection and transfer devices commonly used for malaria RDTs were assessed for their consistency, accuracy and ease of use in the hands of laboratory technicians and village health workers.
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Research
Sedigheh Zakeri, Mandana Afsharpad, Ahmad Raeisi, Navid Djadid Malaria Journal 2007, 6:148 (13 November 2007) A useful study of the prevalence of mutations in the genes associated with resistance to chloroquine and sulphadoxine-pyrimethamine, which fills a gap in the available information on the distribution of these molecular markers in the region.
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Research
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children Henry B Armah, Nana O Wilson, Bismark Y Sarfo, Michael D Powell, Vincent C Bond, Winston Anderson, Andrew A Adjei, Richard K Gyasi, Yao Tettey, Edwin K Wiredu, Jon Tongren, Venkatachalam Udhayakumar, Jonathan K Stiles Malaria Journal 2007, 6:147 (12 November 2007) The balance between specific cytokines and chemokines produced in response to infection is thought to play an important role in various forms of severe malaria. This study investigates the behaviour of 36 different biomarkers and identifies new clues for understanding pathophysiological events.
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Research
Abdunoor M Kabanywanyi, Alex Mwita, Deborah Sumari, Renata Mandike, Kefas Mugittu, Salim Abdulla Malaria Journal 2007, 6:146 (11 November 2007) This study provides useful data on efficacy of the two currently deployed ACTs in Africa, AQ+AS and AL. Tanzania mainland has adopted AL first line since this trial, and Zanzibar AQ+AS. The efficacy and side-effects of these drugs are important questions and, despite their widespread deployment, there is remarkable little published literature outside a few major randomized trials.
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Case study
Incorporating a quiz into informed consent processes: Qualitative study of participants' reactions Sassy Molyneux, Caroline Gikonyo, Vicki Marsh, Philip Bejon Malaria Journal 2007, 6:145 (10 November 2007) Formal checks of participant understanding are widely recommended to improve informed consent processes. The quiz prompted community members to voice concerns about blood sampling and vaccine side-effects, but it also caused significant upset and concern, as some of the quiz questions appeared to fuel misconceptions and fears, with potentially negative consequences for both the study and community members.
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Research
Lena Hommerich, Christa von Oertzen, George Bedu-Addo, Ville Holmberg, Patrick A Acquah, Teunis A Eggelte, Ulrich Bienzle, Frank P Mockenhaupt Malaria Journal 2007, 6:144 (8 November 2007) In southern Ghana, placental malaria and maternal anaemia have declined substantially after the implementation of IPTp-SP. Conceivably, these effects can further be increased by improving IPTp-SP coverage and adherence. The main finding is a decrease in malariometric measures in pregnant women in 2006 compared to 2000.
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