Malaria Journal

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Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children

Denise Njama-Meya*, Tamara D Clark, Bridget Nzarubara, Sarah Staedke, Moses R Kamya and Grant Dorsey

Malaria Journal 2007, 6:7 doi:10.1186/1475-2875-6-7

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BioMed Central: 12 citations

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Treatment guided by rapid diagnostic tests for malaria in Tanzanian children: safety and alternative bacterial diagnoses

George Mtove, Ilse CE Hendriksen, Ben Amos, Hedwiga Mrema, Victor Mandia, Alphaxard Manjurano, Florida Muro, Alma Sykes, Helena Hildenwall, Christopher JM Whitty, Hugh Reyburn Malaria Journal 2011, 10:290 (6 October 2011)

Use of RDTs to direct the use of anti-malarial drugs in young children did not result in any missed diagnoses of malaria although new infections soon after a consultation with a negative RDT result may undermine confidence in results.

Research article   Open Access

Prospective study on severe malaria among in-patients at Bombo regional hospital, Tanga, north-eastern Tanzania

Hamisi A Msangeni, Mathias L Kamugisha, Samuel H Sembuche, Ezekiel K Malecela, Juma A Akida, Filbert F Temba, Bruno P Mmbando, Martha M Lemnge BMC Infectious Diseases 2011, 11:256 (29 September 2011)

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Confirmed malaria cases among children under five with fever and history of fever in rural western Tanzania

Humphrey D Mazigo, Wilfred Meza, Emanuella E Ambrose, Benson R Kidenya, Eliningaya J Kweka BMC Research Notes 2011, 4:359 (13 September 2011)

Research   Open Access

Strict adherence to malaria rapid test results might lead to a neglect of other dangerous diseases: a cost benefit analysis from Burkina Faso

Zeno Bisoffi, Sodiomon B Sirima, Filip Meheus, Claudia Lodesani, Federico Gobbi, Andrea Angheben, Halidou Tinto, Bouma Neya, Klara Van den Ende, Annalisa Romeo, Jef Van den Ende Malaria Journal 2011, 10:226 (4 August 2011)

Paper addresses the important matter of correct malaria management by using rapid diagnostic tests (RDTs), which challenges health workers in malaria endemic areas. The presented study was designed to estimate the costs and benefits of a strategy of presumptive management of malaria-attributable fever compared to RDT-based management in a rural setting in Burkina Faso, and the consequences of not providing antibiotic treatment to patients who may need it following a false positive test result.

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Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda

Daniel J Kyabayinze, Caroline Asiimwe, Damalie Nakanjako, Jane Nabakooza, Helen Counihan, James K Tibenderana Malaria Journal 2010, 9:200 (12 July 2010)

A study of the effect on prescribing practices of introducing RDTs with basic training in Ugandan primary care facilities. The findings are important for the current roll out of RDTs and the recent switch from presumptive to parasitological diagnosis of malaria in children.

Research   Open Access

Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine Malaria Journal 2009, 8:237 (24 October 2009)

Prophylaxis of malaria among people with sickle cell anaemia is a topical issue: suggested that people with sickle cell aneamia are a neglected population.

Research   Open Access

Fever treatment in the absence of malaria transmission in an urban informal settlement in Nairobi, Kenya

Yazoume Ye, Nyovani Madise, Robert Ndugwa, Sam Ochola, Robert W Snow Malaria Journal 2009, 8:160 (15 July 2009)

The study could not demonstrate any evidence of malaria in Korogocho, a slum in the centre of Nairobi. Fever was a common complaint and often treated as malaria with anti-malarial drugs. Strategies, including testing for malaria parasites to reduce the inappropriate exposure of poor communities to expensive anti-malarial drugs provided by clinical services and drug vendors, should be a priority for district planners.

Review   Open Access

Working without a blindfold: the critical role of diagnostics in malaria control

Mark D Perkins, David R Bell Malaria Journal 2008, 7(Suppl 1):S5 (11 December 2008)

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Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria

Charles Mwanziva, Seif Shekalaghe, Arnold Ndaro, Bianca Mengerink, Simon Megiroo, Frank Mosha, Robert Sauerwein, Chris Drakeley, Roly Gosling, Teun Bousema Malaria Journal 2008, 7:232 (5 November 2008)

Research   Open Access

Impact of training in clinical and microscopy diagnosis of childhood malaria on antimalarial drug prescription and health outcome at primary health care level in Tanzania: A randomized controlled trial

Billy Ngasala, Marycelina Mubi, Marian Warsame, Max G Petzold, Amos Y Massele, Lars L Gustafsson, Goran Tomson, Zul Premji, Anders Bjorkman Malaria Journal 2008, 7:199 (2 October 2008)

An important addition to the evidence-base on the role of diagnostics in malaria case-management. While the study shows a benefit of microscopy in reducing the prescription of antimalarial drugs, the problems with quality of microscopy raise concerns about the viability of the approach, as opposed to rapid diagnostic tests for expanding the use of malaria diagnostics in the current new era of ACT

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Guidelines and mindlines: why do clinical staff over-diagnose malaria in Tanzania? A qualitative study

Clare IR Chandler, Caroline Jones, Gloria Boniface, Kaseem Juma, Hugh Reyburn, Christopher JM Whitty Malaria Journal 2008, 7:53 (2 April 2008)

An important topic in malaria control at a time when new and costly drugs regimens are chosen for first line treatment of uncomplicated malaria in many endemic countries. In-depth understanding of the reasons for the common practice of over-diagnosis of malaria is pertinent in trying to change inappropriate habits.

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The burden of disease profile of residents of Nairobi's slums: Results from a Demographic Surveillance System

Catherine Kyobutungi, Abdhalah Ziraba, Alex Ezeh, Yazoumé Yé Population Health Metrics 2008, 6:1 (10 March 2008)