Figure 4.

Lymph nodes/Peyer's patches. A) lymph node of infected mouse (day 7). Disorganized germinal center (Gc), with small lymphocytes permeating an area of centroblastic proliferation, with several apoptotic bodies (white arrows). Paracortical area (Pc) with high endothelial venules (black arrows). Giemsa. B) lymph node of infected mouse (day 7). Medullary cords showing increased numbers of trafficking small lymphocytes and some immunoblasts (arrows). Giemsa. C) Panoramic view of Peyer patches of non-infected control mouse. Giemsa. D) Peyer patch of non-infected control mouse. Macrophages (arrows) permeating small lymphocytes. Haematoxylin-eosin. E) Panoramic view of Peyer patches of infected mouse (day 7), showing shrinkage of the patch. Giemsa. F) Peyer patch of infected mouse (day 7). Lymphocyte depletion and apoptosis foci (arrows). Haematoxylin-eosin.