Figure 2.

Spleen. A) Panoramic view of non-infected control mouse spleen. White and red pulps (Rp) with well-defined limits. Two B cell resting follicles (Flc) with surrounding thick marginal zones (Mz). Giemsa. B) T cell area (periarteriolar lymphoid sheath) of infected mouse (day 3). Immunoblasts (arrows). Giemsa. C) Infected mouse (day 3). Deposit of fibrinoid material (Fb) between T zone (Tz) and red pulp (Rp). Haematoxylin-eosin. D) Infected mouse (day 6). Disorganized germinal center with intense centroblast (Ct) activation and proliferation and apoptosis (white arrows), without centrocyte differentiation. Small lymphocytes (black arrows) permeating the disorganized germinal center. Giemsa. E) Panoramic view of infected mouse spleen (day 6). Disorganized germinal center (Gc), without definition of light and dark areas, absent marginal zone and blurred limits between white and red pulps (Rp). Haematoxylin-eosin. F) Infected mouse (day 6). Blurred limits in the border between disorganized germinal center (Gc) and red pulp (Rp), absent marginal zone, and malarial pigment in red pulp macrophages. Giemsa.