Malaria Journal

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Paracheck-Pf® accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?

Todd D Swarthout*, Helen Counihan, Raphael KK Senga and Ingrid van den Broek

Malaria Journal 2007, 6:58 doi:10.1186/1475-2875-6-58

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BioMed Central: 11 citations

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Reducing malaria misdiagnosis: the importance of correctly interpreting Paracheck Pf® "faint test bands" in a low transmission area of Tanzania

Lisa K Allen, Jennifer M Hatfield, Giselle DeVetten, Jeremy C Ho, Mange Manyama BMC Infectious Diseases 2011, 11:308 (3 November 2011)

Research   Open Access Highly Accessed

Placental Plasmodium falciparum malaria infection: Operational accuracy of HRP2 rapid diagnostic tests in a malaria endemic setting

Daniel J Kyabayinze, James K Tibenderana, Mercy Nassali, Lynette K Tumwine, Clare Riches, Mark Montague, Helen Counihan, Prudence Hamade, Jean-Pierre Van Geertruyden, Sylvia Meek Malaria Journal 2011, 10:306 (18 October 2011)

Hospital-based operational study comparing the accuracy of an HRP-2 specific rapid diagnostic test (RDT) to Giemsa light microscopy in the diagnosis of falciparum malaria in a hyper-endemic setting.

Review   Open Access

Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

Sibylle Gerstl, Sophie Dunkley, Ahmed Mukhtar, Martin De Smet, Samuel Baker, Jacob Maikere Malaria Journal 2010, 9:28 (21 January 2010)

The information is relevant, as there is an ongoing search to design and implement a malaria RDT that is appropriate in developing country settings.

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Use and limitations of malaria rapid diagnostic testing by community health workers in war-torn Democratic Republic of Congo

Michael Hawkes, Jean Katsuva, Claude K Masumbuko Malaria Journal 2009, 8:308 (23 December 2009)

This article provides an interesting description of feasibility and results of scaling up to provide rapid diagnosis of malaria in a difficult, war-torn setting. It is unique in this respect.

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PfHRP2 and PfLDH antigen detection for monitoring the efficacy of artemisinin-based combination therapy (ACT) in the treatment of uncomplicated falciparum malaria

Sandrine Houzé, Mainoumata Boly, Jacques Le Bras, Philippe Deloron, Jean-François Faucher Malaria Journal 2009, 8:211 (7 September 2009)

Research   Open Access

Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda

Daniel J Kyabayinze, James K Tibenderana, George W Odong, John B Rwakimari, Helen Counihan Malaria Journal 2008, 7:221 (29 October 2008)

Paper dealing with the important topic of the accuracy of RDTs and presence of false positives due to persistent HRP2 antigen.

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Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands

Tarekegn A Abeku, Mojca Kristan, Caroline Jones, James Beard, Dirk H Mueller, Michael Okia, Beth Rapuoda, Brian Greenwood, Jonathan Cox Malaria Journal 2008, 7:202 (3 October 2008)

This paper raises very important issues with long-reaching implications for the cost-effectiveness of diagnosing and treating malaria in endemic areas.

Research   Open Access

Impact of training in clinical and microscopy diagnosis of childhood malaria on antimalarial drug prescription and health outcome at primary health care level in Tanzania: A randomized controlled trial

Billy Ngasala, Marycelina Mubi, Marian Warsame, Max G Petzold, Amos Y Massele, Lars L Gustafsson, Goran Tomson, Zul Premji, Anders Bjorkman Malaria Journal 2008, 7:199 (2 October 2008)

An important addition to the evidence-base on the role of diagnostics in malaria case-management. While the study shows a benefit of microscopy in reducing the prescription of antimalarial drugs, the problems with quality of microscopy raise concerns about the viability of the approach, as opposed to rapid diagnostic tests for expanding the use of malaria diagnostics in the current new era of ACT

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Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?

Charlotte M Zikusooka, Diane McIntyre, Karen I Barnes Malaria Journal 2008, 7:176 (15 September 2008)

The use of RDTs in all suspected cases has been shown to be cost-saving, but findings also show that targeting RDTs at the group over six years og age and treating children less than six years on the basis of clinical diagnosis is even more cost-saving.

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Performance and usefulness of the Hexagon rapid diagnostic test in children with asymptomatic malaria living in the Mount Cameroon region

Samuel Wanji, Helen K Kimbi, Joan E Eyong, Nicholas Tendongfor, Judith L Ndamukong Malaria Journal 2008, 7:89 (22 May 2008)

A study of the performance of a pLDH-based RDT for mass surveillance

Research   Open Access Highly Accessed

An interactive model for the assessment of the economic costs and benefits of different rapid diagnostic tests for malaria

Yoel Lubell, Heidi Hopkins, Christopher JM Whitty, Sarah G Staedke, Anne Mills Malaria Journal 2008, 7:21 (28 January 2008)

An interactive model was designed to compare different diagnostic strategies. Variables included in the model can be modified by users, including RDT and treatment costs, test accuracies (sensitivity and specificity), probabilities for developing severe illness, case-fatality rates, and clinician response to negative test results.