Table 1 |
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|
Physiological and clinical variables during first 7 days of RICU stay demonstrating the effect of the infusion of Drotrecogin alfa (activated) on days 1–4. |
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| Variables |
Day 0 |
Day 1 |
Day 2 |
Day 3 |
Day 4 |
Day 5 |
Day 6 |
Day 7 |
|
|
||||||||
| Heart rate (/minute) |
128 |
111 |
120 |
116 |
106 |
100 |
92 |
86 |
| Respiratory rate (/minute) |
46 |
32 |
36 |
30 |
28 |
28 |
24 |
22 |
| Temperature (C) |
39 |
38.5 |
38.4 |
38 |
37 |
37 |
37 |
37.2 |
| pH |
7.2 |
7.25 |
7.26 |
7.3 |
7.34 |
7.42 |
7.44 |
- |
| PaO2/FiO2 |
168 |
180 |
130 |
230 |
260 |
290 |
340 |
- |
| HCO3 (mEq/L) |
13 |
15 |
14 |
18 |
20 |
22 |
22 |
- |
| Ventilatory mode |
Spontaneous |
ACMV |
ACMV |
ACMV |
PSV |
T-piece |
Spontaneous |
Spontaneous |
| PEEP (cm H20) |
- |
8 |
10 |
6 |
5 |
- |
- |
- |
| Serum creatinine (mg/dL) |
5.2 |
6.0 |
5.2 |
7.1 |
4.6 |
4.4 |
4.0 |
3.6 |
| Urine output (mL/24 hours) |
460 |
100 |
110 |
200 |
240 |
200 |
270 |
560 |
| Serum bilirubin (mg/dL) |
18.2 |
18.9 |
18.2 |
15.4 |
9.1 |
8.4 |
6.0 |
4.2 |
| Total leucocyte count (/μL) |
19000 |
19500 |
18200 |
14400 |
11400 |
8100 |
8000 |
8100 |
| Platelet count (/μL) |
92000 |
105,000 |
155,000 |
183,000 |
212,000 |
241,000 |
260,000 |
270,000 |
|
|
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|
Srinivas et al. Malaria Journal 2007 6:42 doi:10.1186/1475-2875-6-42 |
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