Malaria Journal

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Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi)

Robin Kobbe, Samuel Adjei, Christina Kreuzberg, Benno Kreuels, Benedicta Thompson, Peter A Thompson, Florian Marks, Wibke Busch, Meral Tosun, Nadine Schreiber, Ernest Opoku, Ohene Adjei, Christian G Meyer and Juergen May*

Malaria Journal 2007, 6:163 doi:10.1186/1475-2875-6-163

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Research   Open Access

Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance

Anne F Gasasira, Moses R Kamya, Edwin O Ochong, Neil Vora, Jane Achan, Edwin Charlebois, Theodore Ruel, Fredrick Kateera, Denise N Meya, Diane Havlir, Philip J Rosenthal, Grant Dorsey Malaria Journal 2010, 9:177 (23 June 2010)

The authors used two contemporaneous, very similar, geographically contiguous cohorts of Ugandan children in order to compare malaria incidence in HIV+ children on daily co-trimoxazole (TS) prophylaxis to incidence in HIV-uninfected children not on daily TS. Recrudescence was distinguished from re-infection using molecular methods.

Research   Open Access

Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon

Jürgen May, Samuel Adjei, Wibke Busch, Julian J Gabor, Saadou Issifou, Robin Kobbe, Benno Kreuels, Bertrand Lell, Norbert G Schwarz, Ohene Adjei, Peter G Kremsner, Martin P Grobusch Malaria Journal 2008, 7:198 (1 October 2008)

The observation that the IPTi effect is mainly therapeutic and prophylactic might limit the selection of drugs eligible for IPTi to those that are long-acting. The unique property of SP as an inexpensive, one-dose anti-malaria drug favours SP, provided that it is not used as first line drug for treating malaria in the same area.