Table 4

IC50s for chloroquine (CQ) quinine (QN), monodesethylamodiaquine (MdAQ) and artemisinin (ART) in nM. Geometric Least Squares Means Ratio between years.


MdAQ
 CQ
 QN
 ART
Variable
 2 one-sided 90% limits
 GLS Mean Ratio (%)
 90%CI
 2sided t p-value
 GLS Mean Ratio (%)
 90%CI
 2sided t p-value
 GLS Mean Ratio (%)
 90%CI
 2sided t-value
 GLS Mean Ratio (%)
 90%CI
 2sided t p-value
1997 vs 2000
 [80,125]
 516.7
 [266.4,1002.3]
 <0.0001
 63.2
 [25.5,156.7]
 N.S.
 131.4
 [69.3,249.2]
 N.S.
 166.8
 [57.2,486.0]
 N.S.
1997 vs 2001
 [80,125]
 452.3
 [230.3,888.2]
 <0.0001
 113.5
 [45.1,285.4]
 N.S.
 193.1
 [103.8,359.2]
 0.005
 110.9
 [38.0,323.0]
 N.S.
1997 vs 2002
 [80,125]
 388.2
 [209.6,719.2]
 <0.0001
 71.3
 [30.7,165.8]
 N.S.
 92.9
 [52.1,165.4]
 N.S.
 110.8
 [39.2,313.4]
 N.S.
1997 vs 2003
 [80,125]
 297.1
 [154.0,573.0]
 <0.0001
 86.2
 [35.0,212.3]
 N.S.
 135.1
 [73.9,247.2]
 N.S.
 175.6
 [61.0,505.7]
 N.S.
1997 vs 2004
 [80,125]
 186.3
 [106.1,326.9]
 0.003
 88.0
 [40.0,193.5]
 N.S.
 89.5
 [52.8,151.6]
 N.S.
 172.5
 [60.3,493.5]
 N.S.
2000 vs 2001
 [80,125]
 87.5
 [42.5,180.4]
 N.S.
 179.6
 [72.4,445.3]
 N.S.
 147.0
 [73.3,294.9]
 N.S.
 66.5
 [31.5,140.3]
 N.S.
2000 vs 2002
 [80,125]
 75.1
 [38.5,146.7]
 N.S.
 112.9
 [49.3,258.3]
 N.S.
 70.7
 [36.6,136.5]
 N.S.
 66.4
 [32.9,134.2]
 N.S.
2000 vs 2003
 [80,125]
 57.5
 [28.4,116.5]
 N.S.
 136.4
 [56.1,331.1]
 N.S.
 102.9
 [52.0,203.3]
 N.S.
 105.3
 [50.7,218.5]
 N.S.
2000 vs 2004
 [80,125]
 36.1
 [19.4,67.0]
 <0.0001
 139.2
 [64.3,301.2]
 N.S.
 68.1
 [36.8,125.9]
 N.S.
 103.4
 [50.3,212.5]
 N.S.
2001 vs 2002
 [80,125]
 85.8
 [43.4,169.6]
 N.S.
 62.8
 [27.0,146.1]
 N.S.
 48.1
 [25.4,91.1]
 0.002
 100.0
 [49.4,202.0]
 N.S.
2001 vs 2003
 [80,125]
 65.7
 [32.0,134.7]
 N.S.
 75.9
 [30.8,187.0]
 N.S.
 70.0
 [36.0,135.8]
 N.S.
 158.4
 [76.3,328.7]
 N.S.
2001 vs 2004
 [80,125]
 41.2
 [21.9,77.5]
 0.000
 77.5
 [35.2,170.5]
 N.S.
 46.3
 [25.6,83.9]
 <0.0001
 155.6
 [75.7,319.8]
 N.S.
2002 vs 2003
 [80,125]
 76.5
 [39.4,148.6]
 N.S.
 120.8
 [53.2,274.6]
 N.S.
 145.5
 [78.0,271.2]
 N.S.
 158.5
 [79.8,314.7]
 N.S.
2002 vs 2004
 [80,125]
 48.0
 [27.1,84.8]
 <0.0001
 123.3
 [61.5,247.2]
 N.S.
 96.3
 [55.7,166.8]
 N.S.
 155.7
 [79.2,305.9]
 N.S.
2003 vs 2004
 [80,125]
 62.7
 [33.9,115.8]
 N.S.
 102.1
 [47.5,219.2]
 N.S.
 66.2
 [37.2,117.9]
 N.S.
 98.2
 [48.6,198.4]
 N.S.

Vaillant and Olliaro Malaria Journal 2007 6:156   doi:10.1186/1475-2875-6-156

Open Data