Table 3

Generalized linear model (SAS System Proc Genmod) of chloroquine (CQ), monodesethylamodiaquine (MdAQ), quinine (QN) and artemisinin (ART) IC50 (nM) with the year as independent parameter (loge-transformed values and 1997 as the reference value).


CQ
 MdAQ
 QN
 ART
Parameter
Estimate
 Std Error
 p
 Estimate
 Std Error
 p
 Estimate
 Std Error
 p
 Estimate
 Std Error
 p
Intercept
4.9
 0.2
 <.0001
 2.1
 0.1
 <.0001
 5.2
 0.1
 <.0001
 1.2
 0.3
 <.0001
year*
 2000
 -0.5
 0.3
 N.S.
 1.6
 0.2
 <.0001
 0.3
 0.2
 N.S.
 0.5
 0.3
 N.S.

2001
 0.1
 0.3
 N.S.
 1.5
 0.2
 <.0001
 0.7
 0.2
 0.0003
 0.1
 0.3
 N.S.

2002
 -0.3
 0.2
 N.S.
 1.4
 0.2
 <.0001
 -0.1
 0.2
 N.S.
 0.1
 0.3
 N.S.

2003
 -0.1
 0.3
 N.S.
 1.1
 0.2
 <.0001
 0.3
 0.2
 N.S.
 0.6
 0.3
 N.S.

2004
 -0.1
 0.2
 N.S.
 0.6
 0.2
 0.0001
 -0.1
 0.2
 N.S.
 0.5
 0.3
 N.S.
Scale
1.1
 0.0
 -
 0.8
 0.0
 -
 0.8
 0.0
 -
 0.8
 0.0
 -

Vaillant and Olliaro Malaria Journal 2007 6:156   doi:10.1186/1475-2875-6-156

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