Table 2

Pairwise Least Squares Means comparisons following ANOVA of chloroquine (CQ), monodesethylamodiaquine (MdAQ), Quinine (QN) and Artemisinin (ART) loge-transformed IC50 (nM) between years.

MdAQ
 CQ
 QN
 ART
year Comparison
 Difference Between Means
 Simultaneous 95% Confidence Limits
Sig.
 Difference Between Means
 Simultaneous 95% Confidence Limits
Sig.
 Difference Between Means
 Simultaneous 95% Confidence Limits
Sig.
 Difference Between Means
 Simultaneous 95% Confidence Limits
Sig.
1997 – 2000
 -1.6
 -2.3
 -1.0
 ***
 0.5
 -0.4
 1.4
-0.3
 -0.9
 0.4
-0.5
 -1.6
 0.5
1997 – 2001
 -1.5
 -2.2
 -0.8
 ***
 -0.1
 -1.0
 0.8
-0.7
 -1.3
 0.0
 ***
 -0.1
 -1.2
 0.9
1997 – 2002
 -1.4
 -2.0
 -0.7
 ***
 0.3
 -0.5
 1.2
0.1
 -0.5
 0.6
-0.1
 -1.1
 0.9
1997 – 2003
 -1.1
 -1.7
 -0.4
 ***
 0.1
 -0.7
 1.0
-0.3
 -0.9
 0.3
-0.6
 -1.6
 0.5
1997 – 2004
 -0.6
 -1.2
 -0.1
 ***
 0.1
 -0.6
 0.9
0.1
 -0.4
 0.6
-0.5
 -1.6
 0.5
2000 – 1997
 1.6
 1.0
 2.3
 ***
 -0.5
 -1.4
 0.4
0.3
 -0.4
 0.9
0.5
 -0.5
 1.6
2000 – 2001
 0.1
 -0.6
 0.8
-0.6
 -1.5
 0.3
-0.4
 -1.1
 0.3
0.4
 -0.3
 1.1
2000 – 2002
 0.3
 -0.4
 0.9
-0.1
 -0.9
 0.7
0.3
 -0.3
 1.0
0.4
 -0.3
 1.1
2000 – 2003
 0.6
 -0.1
 1.2
-0.3
 -1.2
 0.6
0.0
 -0.7
 0.6
-0.1
 -0.8
 0.7
2000 – 2004
 1.0
 0.4
 1.6
 ***
 -0.3
 -1.1
 0.4
0.4
 -0.2
 1.0
0.0
 -0.7
 0.7
2001 – 1997
 1.5
 0.8
 2.2
 ***
 0.1
 -0.8
 1.0
0.7
 0.0
 1.3
 ***
 0.1
 -0.9
 1.2
2001 – 2000
 -0.1
 -0.8
 0.6
0.6
 -0.3
 1.5
0.4
 -0.3
 1.1
-0.4
 -1.1
 0.3
2001 – 2002
 0.2
 -0.5
 0.8
0.5
 -0.4
 1.3
0.7
 0.1
 1.4
 ***
 0.0
 -0.7
 0.7
2001 – 2003
 0.4
 -0.3
 1.1
0.3
 -0.6
 1.2
0.4
 -0.3
 1.0
-0.5
 -1.2
 0.3
2001 – 2004
 0.9
 0.3
 1.5
 ***
 0.3
 -0.5
 1.0
0.8
 0.2
 1.4
 ***
 -0.4
 -1.2
 0.3
2002 – 1997
 1.4
 0.7
 2.0
 ***
 -0.3
 -1.2
 0.5
-0.1
 -0.6
 0.5
0.1
 -0.9
 1.1
2002 – 2000
 -0.3
 -0.9
 0.4
0.1
 -0.7
 0.9
-0.3
 -1.0
 0.3
-0.4
 -1.1
 0.3
2002 – 2001
 -0.2
 -0.8
 0.5
-0.5
 -1.3
 0.4
-0.7
 -1.4
 -0.1
 ***
 0.0
 -0.7
 0.7
2002 – 2003
 0.3
 -0.4
 0.9
-0.2
 -1.0
 0.6
-0.4
 -1.0
 0.2
-0.5
 -1.1
 0.2
2002 – 2004
 0.7
 0.2
 1.3
 ***
 -0.2
 -0.9
 0.5
0.0
 -0.5
 0.6
-0.4
 -1.1
 0.2
2003 – 1997
 1.1
 0.4
 1.7
 ***
 -0.1
 -1.0
 0.7
0.3
 -0.3
 0.9
0.6
 -0.5
 1.6
2003 – 2000
 -0.6
 -1.2
 0.1
0.3
 -0.6
 1.2
0.0
 -0.6
 0.7
0.1
 -0.7
 0.8
2003 – 2001
 -0.4
 -1.1
 0.3
-0.3
 -1.2
 0.6
-0.4
 -1.0
 0.3
0.5
 -0.3
 1.2
2003 – 2002
 -0.3
 -0.9
 0.4
0.2
 -0.6
 1.0
0.4
 -0.2
 1.0
0.5
 -0.2
 1.1
2003 – 2004
 0.5
 -0.1
 1.1
0.0
 -0.8
 0.7
0.4
 -0.2
 1.0
0.0
 -0.7
 0.7
2004 – 1997
 0.6
 0.1
 1.2
 ***
 -0.1
 -0.9
 0.6
-0.1
 -0.6
 0.4
0.5
 -0.5
 1.6
2004 – 2000
 -1.0
 -1.6
 -0.4
 ***
 0.3
 -0.4
 1.1
-0.4
 -1.0
 0.2
0.0
 -0.7
 0.7
2004 – 2001
 -0.9
 -1.5
 -0.3
 ***
 -0.3
 -1.0
 0.5
-0.8
 -1.4
 -0.2
 ***
 0.4
 -0.3
 1.2
2004 – 2002
 -0.7
 -1.3
 -0.2
 ***
 0.2
 -0.5
 0.9
0.0
 -0.6
 0.5
0.4
 -0.2
 1.1
2004 – 2003
 -0.5
 -1.1
 0.1
0.0
 -0.7
 0.8
-0.4
 -1.0
 0.2
0.0
 -0.7
 0.7

Vaillant and Olliaro Malaria Journal 2007 6:156   doi:10.1186/1475-2875-6-156