Table 4

Comparison of Selected CSF Biomarker Median Ratios between the three Study Groups

PRO-INFLAMMATORY OR ANGIOSTATIC vs. ANTI-INFLAMMATORY OR ANGIOGENIC BIOMARKER MEDIAN RATIO

CM

SMA

NM

OVERALL P VALUE

TNF-α : IL-10

3.33 × 10^-2

7.51 × 10^-2

2.04 × 10^-1

NSS

TNF-α : IL-8

7.76 × 10^-2

7.52 × 10^-1

6.67 × 10^-1

NSS

TNF-α : PDGFbb

5.05 × 10^-2

7.56 × 10^-2

1.53 × 10^-2

NSS

IP-10 : IL-10

10.28

2.07

3.14

NSS

IP-10 : IL-8

23.08

20.12

10.29

NSS

IP-10 : PDGFbb

15.35

2.28

2.32 × 10^-2

0.003

Median ratios of CSF levels of pro-inflammatory/angiostatic versus anti-inflammatory/angiogenic biomarkers were compared between the three disease groups; P < 0.05 considered statistically significant; NSS, not statistically significant.

Armah et al. Malaria Journal 2007 6:147   doi:10.1186/1475-2875-6-147