Table 1 |
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|
Main characteristics of the area and intervention in Ifakara and Manhiça |
||
| Ifakara |
Manhiça |
|
|
|
||
| Years of intervention |
1999–2001 |
2002–2004 |
| Number of children randomized |
701 |
1503 |
| Incidence of malaria in placebo groupa |
0.36 |
0.43 |
| EIR* |
29 |
38 |
| Transmission |
Perennial |
Perennial with marked seasonality |
| IPTi regimen** |
2, 3, 9 |
3, 4, 9 |
| Iron supplementation** |
2–6 |
- |
| 1st line Malaria Treatment during study |
SP |
SP + AQ |
| ITN use |
68% |
0 |
| HIV seroprevalence (at ANC) |
6.7% |
19% |
| Hb AS prevalence *** |
12% |
0 |
| SP parasitological sensitivity# |
69% (62/90) |
78.6% (55/70) |
| SP ACR# |
94% (84/89) |
83% (67/81) |
|
|
||
|
*EIR = Entomological inoculation rate **months of age *** hemoglobin AS genotype # at day 14. ACR = adequate clinical response a episode/child/year |
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|
Menendez et al. Malaria Journal 2007 6:132 doi:10.1186/1475-2875-6-132 |
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