Table 3 |
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|
A. Sensitivity and specificity of all three molecular techniques and microscopy using molecular consensus as the gold standard; and B. microscopy as the gold standard |
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| A |
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|
|
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| Molecular consensus as gold standard |
P. falciparum |
P. vivax |
Mixed Infection |
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|
|
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| Sensitivity (%) |
Specificity (%) |
Sensitivity (%) |
Specificity (%) |
Sensitivity (%) |
Specificity (%) |
|
|
|
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| Multiplex |
100 (40/40+0) |
100 (96/96+0) |
92.7 (51/51+4) |
100 (81/81+0) |
0 (0/0+3) |
100 (133/133+0) |
| Nested |
100 (40/40+0) |
99 (95/95+1) |
100 (54/54+0) |
100 (82/82+0) |
100 (3/3+0) |
99.2 (132/132+1) |
| Real-time |
100 (40/40+0) |
100 (96/96+0) |
100 (51/51+0) |
100 (85/85+0) |
100 (3/3+0) |
100 (133/133+0) |
| Microscopy |
92.5 (37/37+3) |
100 (96/96+0) |
90.7 (49/49+5) |
91.5 (75/75+7) |
66.7 (2/2+1) |
98.5 (131/131+2) |
| B |
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| Microscopy as gold standard |
P. falciparum |
P. vivax |
Mixed Infection |
|||
|
|
||||||
| Sensitivity (%) |
Specificity (%) |
Sensitivity (%) |
Specificity (%) |
Sensitivity (%) |
Specificity (%) |
|
|
|
||||||
| Multiplex |
100 (37/37+0) |
97 (96/96+3) |
83.9 (47/47+9) |
95 (76/76+4) |
0 (0/0+4) |
100.00 (132/132+0) |
| Nested |
100 (37/37+0) |
96 (95/95+4) |
87.5 (49/49+7) |
93.8 (75/75+5) |
50 (2/2+2) |
98.5 (130/130+2) |
| Real-time |
100 (37/37+0) |
97 (96/96+3) |
87.5 (49/49+7) |
93.8 (75/75+5) |
50 (2/2+2) |
99.2 (131/131+1) |
|
|
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|
Sensitivity equals the number of true positives divided by the number of true positives and false negatives combined. Specificity equals the number of true negatives divided by the number of true negatives and false positives combined. |
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|
Boonma et al. Malaria Journal 2007 6:124 doi:10.1186/1475-2875-6-124 |
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