World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology
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* Corresponding author: Karen I Barnes karen.barnes@uct.ac.za
Malaria Journal 2007, 6:122 doi:10.1186/1475-2875-6-122
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BioMed Central: 4 citations
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Methodology
Kris M Jamsen, Stephen B Duffull, Joel Tarning, Niklas Lindegardh, Nicholas J White, Julie A Simpson Malaria Journal 2011, 10:181 (1 July 2011) This article presents a novel and successful attempt to rationalize the sampling schedules for PK studies of anti-malarials given unavoidable practical constraints. It provides a practical guide to those designing population PK studies specifically of oral artesunate, and a "proof of principle" for applying optimal design methodology for anti-malarials in general.
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Research
Stéphane Picot, Piero Olliaro, Frédérique de Monbrison, Anne-Lise Bienvenu, Ric N Price, Pascal Ringwald Malaria Journal 2009, 8:89 (4 May 2009) This meta-analysis brings together available data on association between various genetic polymorphisms in Plasmodium falciparum and clinical treatment failure of anti-malarial drugs, and is a valuable summary of the published literature on this topic.
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Methodology
Jonathan J Juliano, Milijaona Randrianarivelojosia, Benjamin Ramarosandratana, Frédéric Ariey, Victor Mwapasa, Steven R Meshnick Malaria Journal 2009, 8:47 (16 March 2009) A study that addresses the important methodological issue of how to detect minor sub-populations of P. falciparum parasites in infected hosts harbouring multiple genotypes.
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Research
Does the drug sensitivity of malaria parasites depend on their virulence? Petra Schneider, Brian HK Chan, Sarah E Reece, Andrew F Read Malaria Journal 2008, 7:257 (16 December 2008) Drug-sensitivity of malaria parasites can be virulence-dependent, with virulent parasites more likely to survive sub-optimal treatment. This study performed in the murine malaria model suggests that the selection imposed by sub-optimal drug treatment could result in the evolution of more aggressive malaria parasites.
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