World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
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* Corresponding author: David J Bacon bacon@nmrcd.med.navy.mil
Malaria Journal 2007, 6:120 doi:10.1186/1475-2875-6-120
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Bécaye Fall, Silmane Diawara, Kowry Sow, Eric Baret, Bakary Diatta, Khadidiatou B Fall, Pape S Mbaye, Fatou Fall, Yaya Diémé, Christophe Rogier, Boubacar Wade, Raymond Bercion, Bruno Pradines Malaria Journal 2011, 10:310 (20 October 2011) The paper describes a steep reduction in the prevalence of chloroquine resistant parasites and an increase in the prevalence of mefloquine resistant parasites in the Dakar region.
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Research
Chloroquine resistance before and after its withdrawal in Kenya Leah Mwai, Edwin Ochong, Abdi Abdirahman, Steven M Kiara, Steve Ward, Gilbert Kokwaro, Philip Sasi, Kevin Marsh, Steffen Borrmann, Margaret Mackinnon, Alexis Nzila Malaria Journal 2009, 8:106 (18 May 2009) Description of a longitudinal study of the prevalence of alleles of P. falciparum that associated with resistance to chloroquine and pyrimethamine in Kilifi, Kenya between 1993 and 2006. This data set was used to calculate the selection coefficient and infer the apparent fitness of the different alleles. This is a salutary reminder that the control of anti-malarial drug use is loose in most settings and the impact of official changes in policy is complex and unpredictable.
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