Figure 5.

Kinetics of antibody response to immunization with Pvs25 in rhesus monkeys. Groups of 5 monkeys were immunized with (i) 15 μg of Pvs25 adsorbed onto 600 μg of alum (blank bars), or (ii) 15 μg of Pvs25 adsorbed onto 600 μg of alum and 250 μg of CpG 10105 (hatched bars). Animals were immunized on days 0, 28 and 181, and bled on days 0, 42, 90 and 195. All sera were tested by ELISA and compared to a standard rhesus anti-Pvs25 serum which has 20,000 units. ELISA values of individual monkeys are plotted and the geometric mean ± SE for the group are also shown.