|
Proportions of point mutations on dhfr and dhps related to parasite resistance to antifolates |
|||||
| Resistance to |
Gene locus |
Mutations (%) |
Wild type (%) |
Mixed (%) |
Total |
|
|
|||||
| Pyrimethamine |
DHFR 51 |
74 (62.7%) |
35 (29.7%) |
9 (7.6%) |
118 |
| DHFR 59 |
59 (48.8%) |
36 (29.8%) |
26 (21.5%) |
121 |
|
| DHFR 108 |
81 (66.9%) |
17 (14.1%) |
23 (19.0%) |
121 |
|
| DHFR 164 |
0 (0.0%) |
104 (100.0%) |
0 (0.0%) |
104 |
|
| Sulphadoxine |
DHPS 437 |
56 (43.7%) |
71 (55.5%) |
1 (0.8%) |
128 |
| DHPS 540 |
47 (39.2%) |
65 (54.5%) |
8 (6.3%) |
120 |
|
| DHPS 581 |
1 (0.8%) |
126 (98.4%) |
1 (0.8%) |
128 |
|
| 318 |
454 |
68 |
840 |
||
Mbugi et al. Malaria Journal 2006 5:94 doi:10.1186/1475-2875-5-94 |
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