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Human malarial disease: a consequence of inflammatory cytokine release

Ian A Clark*, Alison C Budd, Lisa M Alleva and William B Cowden

Malaria Journal 2006, 5:85 doi:10.1186/1475-2875-5-85

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Changes in the levels of cytokines, chemokines and malaria-specific antibodies in response to Plasmodium falciparum infection in children living in sympatry in Mali

Stephanie Bostrom, Pablo Giusti, Charles Arama, Jan-Olov Persson, Victor Dara, Boubacar Traore, Amagana Dolo, Ogobara Doumbo, Marita Troye-Blomberg Malaria Journal 2012, 11:109 (5 April 2012)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The paper describes the levels of several different mediators (cytokines, chemokines) and parasite-specific antibody responses in Fulani and Dogon children.

Research   Open Access

Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism

Tiago S Medina, Sheyla PT Costa, Maria D Oliveira, Ana M Ventura, José M Souza, Tassia F Gomes, Antonio CR Vallinoto, Marinete M Póvoa, João S Silva, Maristela G Cunha Malaria Journal 2011, 10:264 (14 September 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cytokines have the ability to influence many aspects of an immune reaction. A disturbed balance in pro- and anti-inflammatory cytokine responses may affect parasitaemia and pathology in vivax malaria. The study provides interesting insights into the importance of IL10 and IFN-gamma gene polymorphisms during Plasmodium vivax infections.

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