Table 1

Examples of artemisinin-based monotherapies and combinations currently sold in Africa for the treatment of uncomplicated falciparum malaria with summarized informations provided by the manufacturer on the accompanying package insert.
Trade name
 Drug substance/s
 Tablet strength (mg)
 Adult dose/s (mg/day)
 Paediatric dose/s (mg/day)
 Duration (days)
 Tablets/package
 Company
Combination products
Artekin – 02
 dihydroartemisinin+ piperaquine
 40/320
 160/1280
 7–10 y 80/640 11–15 y 60/480
 2
 8
 Hualijian
Artekin
 dihydroartemisinin+ piperaquine
 40/320
 160/1280
 7–10 y 80/640 11–15 y 60/480
 2
 8
 Holleykin pharmaceutical
Duo-cotecxin
 dihydroartemisinin+ piperaquine
 40/320
 160/1280
 7–10 y 80/640 11–15 60/480
 2
 8
 Beijing Holley-Cotec
Coartem
 artemether+ lumefantrine
 20/120
 D1 160/960, D2-3 80/480 or D1-3 160/960
 5–15 kg 40/240 16–25 kg 80/480 26–35 kg 120/720
 3
 16–24
 Novartis
Artequin
 artesunate + mefloquine
 200/250
 200/250
 NA
 3
 3 + 3
 Mepha
Arsucam (infants and children)
 artesunate + amodiaquine
 50/153
 NA
 1–7 y 50/153 7–13 y 100/306
 3 3
 3 + 3 6 + 6
 Sanofi-Aventis
Arsucam (adults)
 artesunate + amodiaquine
 50/153
 200/612
 NA
 3
 12 + 12
 Sanofi-Aventis
Larimal
 artesunate + amodiaquine
 50/153
 200/612
 4 mg/kg (AS) + 10 mg/kg (AM)
 3
 12 + 12
 Ipca
Monotherapies
Artesunate tablets
 artesunate
 50
 D1 200, D2-5 100
 NA
 5
 6
 Guilin pharmaceutical
Arinate
 artesunate
 100
 D1 200, D2-5 100
 D1 3.2 mg/kg, D2-5 1.6 mg/kg
 5
 6
 Dafra
Arsumax
 artesunate
 50
 D1 200, D2-5 100
 D1 4 mg/kg, D2-5 2 mg/kg
 5
 12
 Sanofi-Aventis
Cotexin
 artesunate
 60
 D1 120, D2-5/7 60
 NA
 5–7
 NA
 Cotec
Artesunate injection
 artesunate
 60
 NA
 NA
 NA
 NA
 Guilin pharmaceutical
Arte-biosorp
 artesunate
 75
 300
 NA
 7
 NA
 Hovid
Artenex
 artesunate
 NA
 D1 4tab, D2-5 2tab
 D1 3.2 mg/kg, D2-5 2 mg/kg
 5
 12
 Kinapharma
Malarin 200
 artesunate
 200
 D1 400, D2-5 200
 D1 4 mg/kg, D2-5 2 mg/kg (infants) D1 200, D2-5 100 (children)
 5
 6
 tri-health
Plasmotrim 200
 artesunate
 200
 D1 400, D2-5 200
 NA
 5
 6
 Mepha
Plasmotrim 50
 artesunate
 50
 NA
 D1 10 mg/kg, D2-5 5 mg/kg
 5
 12
 Mepha
Gvither forte kit injection
 artemether
 80
 D1 240, D2-5 80
 D1 4 mg/kg, D2-5 2 mg/kg
 5
 6
 Gvs labs
Gvither forte tablets
 artemether
 80
 D1 240, D2-5 80
 D1 4 mg/kg, D2-5 2 mg/kg
 5
 6
 Gvs labs
Larither capsule
 artemether
 40
 D1 4 mg/kg, D2-5 2 mg/kg
 NA
 7
 6
 Ipca
Capsulae artemetheri
 artemether
 40
 D1 160, D2-5 80
 NA
 5–7
 10
 Kunming pharmaceutical
Arte-biosorp
 artemisinin
 75
 150
 NA
 7
 30
 Hovid
Malaxin
 dihydroartemisinin
 60
 D1 120, D2-5/7 60
 NA
 7
 8
 Cho dang pharmaceutical
Cotecxin
 dihydroartemisinin
 60
 D1 120, D2-5/7 60
 D1 60, D2-7 30
 7
 8
 Jiaxing nanhu

Abbreviations: NA: information not available. D1,2,3: first, second, third day of treatment. Y: year. Tab: tablets

Jackson et al. Malaria Journal 2006 5:81   doi:10.1186/1475-2875-5-81

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