Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola
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* Corresponding author: Luís Varandas varandas@ihmt.unl.pt
Malaria Journal 2006, 5:30 doi:10.1186/1475-2875-5-30
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Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing Richard L Culleton, Toshihiro Mita, Mathieu Ndounga, Holger Unger, Pedro VL Cravo, Giacomo M Paganotti, Nobuyuki Takahashi, Akira Kaneko, Hideaki Eto, Halidou Tinto, Corine Karema, Umberto D'Alessandro, Virgilio do Rosário, Takatoshi Kobayakawa, Francine Ntoumi, Richard Carter, Kazuyuki Tanabe Malaria Journal 2008, 7:174 (11 September 2008) The paper sought to detect P. vivax in samples collected from many different sites in West, Central and East Africa. An extensive number of blood samples (2588) were collected and the presence of the parasite ascertained by PCR amplification. No P. vivax could be detected except in one sample from Sao Tome and Principe, where the presence of P. vivax had been previously noted.
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Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites Marie-Thérèse Ekala, Nimol Khim, Eric Legrand, Milijaona Randrianarivelojosia, Ronan Jambou, Thierry Fandeur, Didier Menard, Serge-Brice Assi, Marie-Claire Henry, Christophe Rogier, Christiane Bouchier, Odile Mercereau-Puijalon Malaria Journal 2007, 6:164 (17 December 2007) A study of sequence variation of Plasmodium falciparum cytochrome b from various locations on three continents discussing possible relevance to clinical failure
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Tamirat Gebru, Asrat Hailu, Peter G Kremsner, Jürgen FJ Kun, Martin P Grobusch Malaria Journal 2006, 5:112 (21 November 2006) In the absence of drug pressure, spontaneous and possibly resistance-conferring mutations are rare. Only 10% mutant types were found in Gabonese isolates and all isolates from Ethiopia were wild-type.
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Christian T Happi, Grace O Gbotosho, Onikepe A Folarin, Danny Milner, Ousmane Sarr, Akintunde Sowunmi, Dennis E Kyle, Wilbur K Milhous, Dyann F Wirth, Ayoade MJ Oduola Malaria Journal 2006, 5:82 (4 October 2006) Report on the frequence of mutations associated with atovaquone resistance in Plasmodium falciparum isolates from three African countries.
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