Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania
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* Corresponding author: Kefas Mugittu kmugittu@ihrdc.or.tz
Malaria Journal 2006, 5:126 doi:10.1186/1475-2875-5-126
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BioMed Central: 4 citations
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Research
Bianca E Gama, Natália de Oliveira, José M de Souza, Fátima Santos, Leonardo JM de Carvalho, Yonne FC Melo, Philip J Rosenthal, Cláudio T Daniel-Ribeiro, Maria Ferreira-da-Cruz Malaria Journal 2010, 9:355 (8 December 2010) Data from a genotyping trial targeting specific genetic polymorphisms in the pfmdr1 and pfatpase6 genes among 119 Plasmodium falciparum samples from Brazil. Even if these markers are only coincidental to artemisinin resistance, the study provides a baseline snapshot of the circulating genotypes, before introducing the drug.
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Polymorphism of PfATPase in Niger: detection of three new point mutations Maman Ibrahim, Nimol Khim, Hassane Adam, Frédéric Ariey, Jean-Bernard Duchemin Malaria Journal 2009, 8:28 (18 February 2009) The paper reports sequence data relative to the SERCA-like ATPase6 gene of Plasmodium falciparum among natural parasite populations of Niger. The PfATPase6 gene has been previously proposed as a putative modulator of response to artemisinins and the data presented may be useful as an additional tool for surveillance of ACT efficacy in this country.
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No PfATPase6 S769N mutation found in Plasmodium falciparum isolates from China Guoqing Zhang, Yayi Guan, Bin Zheng, Song Wu, Linhua Tang Malaria Journal 2008, 7:122 (8 July 2008) The results suggest that the S769N mutation is not yet common in China, despite years of artemisinin misuse as a monotherapy and reports of decreased clinical susceptibility.
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Eliningaya J Kweka, Watoky MM Nkya, Aneth M Mahande, Charles Assenga, Franklin W Mosha, Ester E Lyatuu, Charles P Massenga, Edwin M Nyale, Stephen B Mwakalinga, Asanterabi Lowassa Malaria Journal 2008, 7:59 (18 April 2008) Today, entomological surveys are still of great importance in decision-making and evaluation of malaria control strategies
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