Efficacy of three artemisinin combination therapies for the treatmentof uncomplicated Plasmodium falciparum malaria in the Republic of Congo
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* Corresponding author: Manica Balasegaram manica.balasegaram@london.msf.org
Malaria Journal 2006, 5:113 doi:10.1186/1475-2875-5-113
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BioMed Central: 9 citations
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Research
William Yavo, Babacar Faye, Thomas Kuete, Vincent Djohan, Serge A Oga, Richard R Kassi, Mariama Diatta, Moor V Ama, Roger Tine, Jean-Louis Ndiaye, Jean-Bedel Evi, Albert Same-Ekobo, Oumar Faye, Moussa Koné Malaria Journal 2011, 10:198 (20 July 2011) In this study performed in three Afican countries, dihydroartemisinin-piperaquine was as effective and well-tolerated as artemether-lumefantrine in the treatment of uncomplicated falciparum malaria. In addition, dihydroartemisinin-piperaquine, a single daily dose, could be at an advantage over artemether-lumefantrine because of better treatment observance.
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Review
Safety profile of Coartem®: the evidence base Catherine Falade, Christine Manyando Malaria Journal 2009, 8(Suppl 1):S6 (12 October 2009) |
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Review
The clinical efficacy of artemether/lumefantrine (Coartem®) Michael Makanga, Srivicha Krudsood Malaria Journal 2009, 8(Suppl 1):S5 (12 October 2009) |
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Research
Julien Zwang, Piero Olliaro, Hubert Barennes, Maryline Bonnet, Philippe Brasseur, Hasifa Bukirwa, Sandra Cohuet, Umberto D'Alessandro, Abdulaye Djimdé, Corine Karema, Jean-Paul Guthmann, Sally Hamour, Jean-Louis Ndiaye, Andreas Mårtensson, Claude Rwagacondo, Issaka Sagara, Albert Same-Ekobo, Sodiomon B Sirima, Ingrid van den Broek, Adoke Yeka, Walter RJ Taylor, Grant Dorsey, Milijaona Randrianarivelojosia Malaria Journal 2009, 8:203 (23 August 2009) This multi-center analysis study addresses efficacy of artesunate-amodiaquine, a very important candidate for the treatment of uncomplicated malaria globally. The analysis of patient-level data examining the efficacy of AS&AQ compared to local standard therapy, makes a strong case for the use of AS&AQ in all transmission settings.
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Research
Francis W Hombhanje, David Linge, Adolf Saweri, Cynthia Kuanch, Robert Jones, Stephen Toraso, Jacobed Geita, Andrew Masta, Isi Kevau, Gilbert Hiawalyer, Mathias Sapuri Malaria Journal 2009, 8:196 (12 August 2009) Paper suggests that the ANQ combination as a single dose administration is safe and effective for the treatment of uncomplicated falciparum malaria in the adult population of Papua New Guinea and deserves further clinical evaluation.
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Research
Robin Kobbe, Philipp Klein, Samuel Adjei, Solomon Amemasor, William Thompson, Hanna Heidemann, Maja V Nielsen, Julia Vohwinkel, Benedikt Hogan, Benno Kreuels, Martina Bührlen, Wibke Loag, Daniel Ansong, Jürgen May Malaria Journal 2008, 7:261 (19 December 2008) Numerous trials have demonstrated high efficacy and safety of artemisinin-based combination therapy (ACT) under supervised treatment but looking how these treatments are applied unsupervised are scarce. Unobserved AL and ASAQ treatment showed high adequate clinical and parasitological responses, though AL was inferior in preventing late clinical failures.
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Research
Petra F Mens, Patrick Sawa, Sandra M van Amsterdam, Inge Versteeg, Sabah A Omar, Henk DFH Schallig, Piet A Kager Malaria Journal 2008, 7:237 (18 November 2008) The component of the study looking at the effects of these drug combinations on gametocyte development is an important issue in malaria control
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Methodology
Elizabeth A Ashley, Loretxu Pinoges, Eleanor Turyakira, Grant Dorsey, Francesco Checchi, Hasifa Bukirwa, Ingrid van den Broek, Issaka Zongo, Pedro Urruta, Michel van Herp, Suna Balkan, Walter R Taylor, Piero Olliaro, Jean-Paul Guthmann Malaria Journal 2008, 7:154 (9 August 2008) Data from different in vivo studies of ACT treatment of uncomplicated falciparum malaria were combined in a single database. Efficacy at day 28 corrected by PCR genotyping was estimated using four methods.
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Research
Germain Mandi, Frank P Mockenhaupt, Boubacar Coulibaly, Peter Meissner, Olaf Müller Malaria Journal 2008, 7:58 (17 April 2008) An interesting study which gives an insight into the decreasing efficacy of amodiaquine in northern Burkina Faso and which addresses the problem of how this resistance will develop when amodiaquine, in combination with other drugs, is used on a large scale.
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