Table 1

Comparison of clinical trials to evaluate the efficacy of chloroquine (CQ) + sulfadoxine/pyrimethamine (SP)
Study Location
 Year
 N
 CQ Efficacy
 SP Efficacy
 CQ + SP Efficacy
 Endpoint in Days
 Comparison of CQ+SP vs. CQ, CQ+SP vs. SP
 Reference
Nigeria
 2004
 153
 n/a
 n/a
 90%
 28
 n/a
 [30]
Laos
 2003
 110
 n/a
 n/a
 93%
 42
 n/a
n/a
 [14]
Bangladesh
 2002
 133
 n/a
 n/a
 72%
 28
 n/a
 [18]
Eastern Uganda
 2002
 280
 n/a
 42%
 60%
 28
 n/a
p = ns
 [21]
Southern Uganda
 2002
 448
 n/a
 70%
 83%
 14
 n/a
p < 0.001
 [12]
Western Uganda
 2001
 141
 93%
 100%
 100%
 14
 p = ns
p = ns
 [13]
Southern Laos
 2001
 119
 55%
 82%
 83%
 14
 p = 0.029
p = ns
 [19]
Papua, Indonesia
 1999
 169
 17%
 79%
 62%
 28
 p < 0.001
p = 0.047
 [17]
Southwest Nigeria
 1999
 111
 93%
 n/a
 96%
 28
 n/a
p = ns
 [22]
Papua New Guinea
 1998–1999
 513*
 n/a
 n/a
 95%
 28
 n/a
 [3]
The Gambia
 1995
 405
 n/a
 90%
 95%
 28
 n/a
p = ns
 [20]
Mumbai, India
 N/a
 49
 36%
 n/a
 87%
 42
 p < 0.026
n/a
 [2]

ns = not significant

n/a = not available

* children were treated with amodiaquine + SP (303 of the 513), ** excluding children

Lederman et al. Malaria Journal 2006 5:108   doi:10.1186/1475-2875-5-108

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