Table 2

cDNA microarray analysis of immunomodulator gene expression in P. yoelii 17XL infected mouse brain at peak parasitemia (day eight post-infection).

GENE NAME

FOLD CHANGE EXPRESSION

DESCRIPTION OF GENE

PECAM-1

23.0

Platelet Endothelia Cell Adhesion Molecule-1

ICAM-1

13.0

Intercellular Adhesion Molecule-1

VCAM-1

6.0

Vascular Cell Adhesion Molecule-1

RANTES

6.0

Regulated upon Activation Normal T cell Expressed and Secreted

INF-γ

6.0

Interferon-gamma

TNF

5.0

Tumor Necrosis Factor-alpha

IL-12

4.0

Interleukin-12

CCR1

4.0

C-C chemokine receptor 1

CCR3

4.0

C-C chemokine receptor 3

CCR5

4.0

C-C chemokine receptor 5

iNOS

4.0

Inducible Nitric Oxide Synthase

ZO-1

2.0

Zonula Occludin -1

IL-4

2.0

Interleukin-4

GDF-2

-2.0

Growth differentiation factor-2

TGF-α

-2.0

Tumor growth factor-alpha

GAPDH

0.0

Glyceraldehyde-3-Phosphate Dehydrogenase

P. yoelii 17XL infection alters immunomudulator gene expression in mouse brain at peak parasitemia (day eight post-infection). cDNA microarray analysis of P. yoelii 17XL infected and uninfected mouse brain. Gene listed were altered > 1.5 fold at peak parasitemia. Fold change in expression is defined as GAPDH normalized mRNA expression ratio of gene signals of infected to uninfected mouse brain.

Sarfo et al. Malaria Journal 2005 4:63   doi:10.1186/1475-2875-4-63