Bone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitaemia
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* Corresponding author: Jorgen AL Kurtzhals j.kurtzhals@dadlnet.dk
Malaria Journal 2005, 4:56 doi:10.1186/1475-2875-4-56
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Review
Human malarial disease: a consequence of inflammatory cytokine release Ian A Clark, Alison C Budd, Lisa M Alleva, William B Cowden Malaria Journal 2006, 5:85 (10 October 2006) Malariologists tend to think that the pathophysiology of malaria is unique. This thought-provoking review shows that much can be learned from events described with other pathogens and that falciparum malaria is primarily an inflammatory cytokine-driven disease. In particular, the inability of mitochondria, through the effects of inflammatory cytokines, to utilise available oxygen may play a crucial role.
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